{"doi":"10.1172/jci132814","title":"Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells","abstract":"The absence of alloantibodies is a feature of transplantation tolerance. Although the lack of T cell help has been evoked to explain this absence, herein we provide evidence for B cell-intrinsic tolerance mechanisms. Using a murine model of heart tolerance, we showed that alloreactive B cells were not deleted but rapidly lost their ability to differentiate into germinal center B cells and secrete donor-specific antibodies. We inferred that tolerant alloreactive B cells retained their ability to sense alloantigen because they continued to drive T cell maturation into CXCR5+PD-1+ T follicular helper cells. Unexpectedly, dysfunctional alloreactive B cells acquired the ability to inhibit antibody production by new naive B cells in an antigen-specific manner. Thus, tolerant alloreactive B cells contribute to transplantation tolerance by foregoing germinal center responses while retaining their ability to function as antigen-presenting cells and by actively suppressing de novo alloreactive B cell responses.","journal":"Journal of Clinical Investigation","year":2020,"id":75520,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9452,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":394623,"name":"Dharmendra Jain","orcid":"0000-0002-8741-1288","position":1,"is_corresponding":false},{"id":106277,"name":"Jianjun Chen","orcid":"0000-0003-3749-2902","position":2,"is_corresponding":false},{"id":396108,"name":"Jinghui Yang","orcid":null,"position":3,"is_corresponding":false},{"id":396109,"name":"Dengping Yin","orcid":null,"position":4,"is_corresponding":false},{"id":394624,"name":"James S. Young","orcid":"0000-0003-2209-2690","position":5,"is_corresponding":false},{"id":270442,"name":"Alexander L. Dent","orcid":"0000-0001-7226-8936","position":6,"is_corresponding":false},{"id":396110,"name":"Roger Sciammas","orcid":null,"position":7,"is_corresponding":false},{"id":92114,"name":"Maria‐Luisa Alegre","orcid":"0000-0001-5707-6194","position":8,"is_corresponding":false},{"id":72297,"name":"Anita S. Chong","orcid":"0000-0003-0460-0196","position":9,"is_corresponding":false},{"id":394622,"name":"Stella H.W. Khiew","orcid":"0000-0001-7514-0348","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:46:55.856612Z","pmid":"32452834","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}