{"doi":"10.1172/jci.insight.94035","title":"Aim2-mediated/IFN-β–independent regulation of gastric metaplastic lesions via CD8+ T cells","abstract":"Development of gastric cancer is often preceded by chronic inflammation, but the immune cellular mechanisms underlying this process are unclear. Here we demonstrated that an inflammasome molecule, absent in melanoma 2 (Aim2), was upregulated in patients with gastric cancer and in spasmolytic polypeptide-expressing metaplasia of chronically Helicobacter felis-infected stomachs in mice. However, we found that Aim2 was not necessary for inflammasome function during gastritis. In contrast, Aim2 deficiency led to an increase in gastric CD8+ T cell frequency, which exacerbated metaplasia. These gastric CD8+ T cells from Aim2-/- mice were found to have lost their homing receptor expression (sphingosine-1-phosphate receptor 1 [S1PR1] and CD62L), a feature of tissue-resident memory T cells. The process was not mediated by Aim2-dependent regulation of IFN-β or by dendritic cell-intrinsic Aim2. Rather, Aim2 deficiency contributed to an increased production of CXCL16 by B cells, which could suppress S1PR1 and CD62L in CD8+ T cells. This study describes a potentially novel function of Aim2 that regulates CD8+ T cell infiltration and retention within chronically inflamed solid organ tissue. This function operates independent of the inflammasome, IFN-β, or dendritic cells. We provide evidence that B cells can contribute to this mechanism via CXCL16.","journal":"JCI Insight","year":2020,"id":62228,"datarank":0.5955437870328184,"base_score":3.970291913552122,"endowment":3.970291913552122,"self_citation_contribution":0.5955437870328184,"citation_network_contribution":0.0,"self_endowment_contribution":0.5955437870328184,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9502,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":109668,"name":"Shrinivas Bishu","orcid":"0000-0003-4823-5805","position":1,"is_corresponding":false},{"id":329026,"name":"Min Zhang","orcid":"0000-0002-1345-0604","position":2,"is_corresponding":false},{"id":329027,"name":"Helmut Grasberger","orcid":"0000-0002-4065-4418","position":3,"is_corresponding":false},{"id":330278,"name":"Guoqing Hou","orcid":null,"position":4,"is_corresponding":false},{"id":296712,"name":"Henry Haley","orcid":null,"position":5,"is_corresponding":false},{"id":294958,"name":"Brock A. Humphries","orcid":"0000-0002-6992-3394","position":6,"is_corresponding":false},{"id":330279,"name":"Li-Jyun Syu","orcid":null,"position":7,"is_corresponding":false},{"id":329028,"name":"Andrzej A. Dlugosz","orcid":"0000-0002-9791-3257","position":8,"is_corresponding":false},{"id":330280,"name":"Kathy Luker","orcid":null,"position":9,"is_corresponding":false},{"id":294970,"name":"Gary D. Luker","orcid":"0000-0001-6832-2581","position":10,"is_corresponding":false},{"id":109670,"name":"Kathryn A. Eaton","orcid":null,"position":11,"is_corresponding":false},{"id":109674,"name":"Nobuhiko Kamada","orcid":"0000-0002-1980-4178","position":12,"is_corresponding":false},{"id":329029,"name":"Marília Cascalho","orcid":"0000-0002-2695-3921","position":13,"is_corresponding":false},{"id":329030,"name":"John Y. Kao","orcid":"0000-0003-1238-8324","position":14,"is_corresponding":false},{"id":329025,"name":"Mohamad El‐Zaatari","orcid":"0000-0002-1752-2599","position":0,"is_corresponding":true}],"reference_count":79,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:10:11.612909Z","pmid":"32053518","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}