{"doi":"10.1172/jci.insight.182589","title":"Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise","abstract":"<jats:p>\n                    Extracellular vesicles (EVs) have emerged as important mediators of intertissue signaling and exercise adaptations. In this human study, we provide evidence that muscle-specific microRNA-1 (miR-1) was transferred to adipose tissue via EVs following an acute bout of resistance exercise. Using a multimodel machine learning automation tool, we discovered muscle primary miR-1 transcript and CD63\n                    <jats:sup>+</jats:sup>\n                    EV count in circulation as top explanatory features for changes in adipose miR-1 levels in response to resistance exercise. RNA-Seq and in-silico prediction of miR-1 target genes identified caveolin 2 (\n                    <jats:italic>CAV2</jats:italic>\n                    ) and tripartite motif containing 6 (\n                    <jats:italic>TRIM6</jats:italic>\n                    ) as miR-1 target genes downregulated in the adipose tissue of a subset of participants with the highest increases in miR-1 levels following resistance exercise. Overexpression of miR-1 in differentiated human adipocyte-derived stem cells downregulated these miR-1 targets and enhanced catecholamine-induced lipolysis. These data identify a potential EV-mediated mechanism by which skeletal muscle communicates with adipose tissue and modulates lipolysis via miR-1.\n                  </jats:p>","journal":"JCI Insight","year":2024,"id":617068,"datarank":0.6880842784163296,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.18298990391835837,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.18298990391835837,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":24,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":669282,"name":"Ahmed Ismaeel","orcid":"0000-0003-4025-3945","position":1,"is_corresponding":false},{"id":859029,"name":"Douglas E. 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Brooks Mobley","orcid":"0000-0002-4045-9962","position":11,"is_corresponding":false},{"id":239247,"name":"Hasiyet Memetimin","orcid":null,"position":12,"is_corresponding":false},{"id":1286987,"name":"Dandan Wang","orcid":"0000-0002-5319-5820","position":13,"is_corresponding":false},{"id":237984,"name":"Brian S. Finlin","orcid":"0000-0001-5594-1818","position":14,"is_corresponding":false},{"id":110441,"name":"Philip A. Kern","orcid":"0000-0002-4761-7417","position":15,"is_corresponding":false},{"id":235329,"name":"Charlotte A. Peterson","orcid":"0000-0001-9340-0705","position":16,"is_corresponding":false},{"id":136426,"name":"John J. McCarthy","orcid":null,"position":17,"is_corresponding":false},{"id":559626,"name":"Yuan Wen","orcid":"0000-0002-3210-1629","position":18,"is_corresponding":false},{"id":1063817,"name":"Benjamin I. 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RNA-Seq and in-silico prediction of miR-1 target genes identified caveolin 2 (\n                    <jats:italic>CAV2</jats:italic>\n                    ) and tripartite motif containing 6 (\n                    <jats:italic>TRIM6</jats:italic>\n                    ) as miR-1 target genes downregulated in the adipose tissue of a subset of participants with the highest increases in miR-1 levels following resistance exercise. Overexpression of miR-1 in differentiated human adipocyte-derived stem cells downregulated these miR-1 targets and enhanced catecholamine-induced lipolysis. These data identify a potential EV-mediated mechanism by which skeletal muscle communicates with adipose tissue and modulates lipolysis via miR-1.\n                  </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39316445","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"R01DK119619,R01DK124626","title":null},{"funder_name":"National Center for Advancing Translational Sciences","grant_id":"UL1TR001998","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01DK119619-04","title":"Exercise-induced skeletal muscle exosomes promote adipocyte lipolysis"},{"funder_name":"National Institutes of Health","grant_id":"5UL1TR001998-02","title":"Kentucky Center for Clinical and Translational Science"},{"funder_name":"National Institutes of Health","grant_id":"5R01DK124626-03","title":"Mechanisms for activation of beige adipose tissue in humans"},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK119619","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK124626","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"T32 HL007344","title":null}],"total_grants":8,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://insight.jci.org/articles/view/182589/files/pdf","host_type":"publisher"},{"url":"https://insight.jci.org/articles/view/182589/files/pdf","host_type":"publisher"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11601556/pdf/jciinsight-9-182589.pdf","host_type":"repository"},{"url":"https://doaj.org/article/bc59f219d06c4bb1948b65036c00de3b","host_type":"repository"},{"url":"https://doi.org/10.1172/jci.insight.182589","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/39316445","host_type":""},{"url":"http://dx.doi.org/10.1172/jci.insight.182589","host_type":""}],"fields_of_study":["0301 basic medicine","03 medical and health sciences","Humans","MicroRNAs","Extracellular Vesicles","Adipose Tissue","Lipolysis","Male","Muscle, Skeletal","Adult","Resistance Training","Female","Young Adult","Adipocytes"],"mesh_terms":["Humans","MicroRNAs","Extracellular Vesicles","Adipose Tissue","Lipolysis","Male","Muscle, Skeletal","Adult","Resistance Training","Female","Young Adult","Adipocytes"],"keywords":["Male","Adult","Lipolysis","Resistance Training","MicroRNAs","Extracellular Vesicles","Young Adult","Adipose Tissue","Adipocytes","Humans","Female","Muscle, Skeletal","Research Article","Metabolism","Muscle biology","Skeletal muscle","Transport"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T00:46:10.381709Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}