{"doi":"10.1172/jci.insight.176065","title":"CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification","abstract":"Vascular calcification is a severe complication of cardiovascular diseases. Previous studies demonstrated that endothelial lineage cells transitioned into osteoblast-like cells and contributed to vascular calcification. Here, we found that inhibition of cyclin-dependent kinase (CDK) prevented endothelial lineage cells from transitioning to osteoblast-like cells and reduced vascular calcification. We identified a robust induction of CDK1 in endothelial cells (ECs) in calcified arteries and showed that EC-specific gene deletion of CDK1 decreased the calcification. We found that limiting CDK1 induced E-twenty-six specific sequence variant 2 (ETV2), which was responsible for blocking endothelial lineage cells from undergoing osteoblast differentiation. We also found that inhibition of CDK1 reduced vascular calcification in a diabetic mouse model. Together, the results highlight the importance of CDK1 suppression and suggest CDK1 inhibition as a potential option for treating vascular calcification.","journal":"JCI Insight","year":2024,"id":442252,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":544075,"name":"Yang Yang","orcid":"0000-0001-6645-2454","position":1,"is_corresponding":false},{"id":389718,"name":"Xiuju Wu","orcid":null,"position":2,"is_corresponding":false},{"id":968619,"name":"Li Zhang","orcid":"0000-0003-2638-2919","position":3,"is_corresponding":false},{"id":526798,"name":"Xinjiang Cai","orcid":"0000-0001-8933-7133","position":4,"is_corresponding":false},{"id":1039701,"name":"Jaden Ji","orcid":null,"position":5,"is_corresponding":false},{"id":1256079,"name":"Sydney Chen","orcid":null,"position":6,"is_corresponding":false},{"id":1256080,"name":"Abigail Vera","orcid":null,"position":7,"is_corresponding":false},{"id":385046,"name":"Kristina I. Boström","orcid":"0000-0002-7745-5025","position":8,"is_corresponding":false},{"id":389001,"name":"Yucheng Yao","orcid":"0000-0003-0483-9180","position":9,"is_corresponding":false},{"id":1039230,"name":"Yan Zhao","orcid":"0000-0001-9233-5809","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-19T02:01:15.932178Z","pmid":"38456502","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}