{"doi":"10.1172/jci.insight.160891","title":"Sustained inhibition of NPY/AgRP neuronal activity by FGF1","abstract":"In rodent models of type 2 diabetes (T2D), central administration of FGF1 normalizes elevated blood glucose levels in a manner that is sustained for weeks or months. Increased activity of NPY/AgRP neurons in the hypothalamic arcuate nucleus (ARC) is implicated in the pathogenesis of hyperglycemia in these animals, and the ARC is a key brain area for the antidiabetic action of FGF1. We therefore sought to determine whether FGF1 inhibits NPY/AgRP neurons and, if so, whether this inhibitory effect is sufficiently durable to offer a feasible explanation for sustained diabetes remission induced by central administration of FGF1. Here, we show that FGF1 inhibited ARC NPY/AgRP neuron activity, both after intracerebroventricular injection in vivo and when applied ex vivo in a slice preparation; we also showed that the underlying mechanism involved increased input from presynaptic GABAergic neurons. Following central administration, the inhibitory effect of FGF1 on NPY/AgRP neurons was also highly durable, lasting for at least 2 weeks. To our knowledge, no precedent for such a prolonged inhibitory effect exists. Future studies are warranted to determine whether NPY/AgRP neuron inhibition contributes to the sustained antidiabetic action elicited by intracerebroventricular FGF1 injection in rodent models of T2D.","journal":"JCI Insight","year":2022,"id":245044,"datarank":0.6219497198416564,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.13323523913843394,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.13323523913843394,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":14,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":315283,"name":"Jarrad M. Scarlett","orcid":"0000-0003-1019-346X","position":1,"is_corresponding":false},{"id":347773,"name":"Arian F. Baquero","orcid":"0000-0003-2153-4688","position":2,"is_corresponding":false},{"id":349420,"name":"Camdin M. Bennett","orcid":null,"position":3,"is_corresponding":false},{"id":292486,"name":"Yanbin Dong","orcid":"0000-0001-7848-7160","position":4,"is_corresponding":false},{"id":479963,"name":"Dominic Chau","orcid":null,"position":5,"is_corresponding":false},{"id":315284,"name":"Jenny M. Brown","orcid":"0000-0002-5072-4491","position":6,"is_corresponding":false},{"id":879447,"name":"Aaron J. Mercer","orcid":"0000-0002-9586-6610","position":7,"is_corresponding":false},{"id":347778,"name":"Thomas H. Meek","orcid":"0000-0002-4922-7009","position":8,"is_corresponding":false},{"id":17051,"name":"Kevin L. Grove","orcid":"0000-0001-5863-3378","position":9,"is_corresponding":false},{"id":322179,"name":"Bao Anh Phan","orcid":null,"position":10,"is_corresponding":false},{"id":315288,"name":"Gregory J. Morton","orcid":"0000-0002-8106-8386","position":11,"is_corresponding":false},{"id":356544,"name":"Kevin W. Williams","orcid":"0000-0002-8434-8658","position":12,"is_corresponding":false},{"id":315289,"name":"Michael W. Schwartz","orcid":"0000-0003-1619-0331","position":13,"is_corresponding":false},{"id":634397,"name":"Eun‐Sang Hwang","orcid":"0000-0002-4298-5368","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:23:34.974895Z","pmid":"35917179","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}