{"doi":"10.1172/jci.insight.160885","title":"Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation","abstract":"Obesity is an important risk factor for atrial fibrillation (AF), but a better mechanistic understanding of obesity-related atrial fibrillation is required. Serum glucocorticoid kinase 1 (SGK1) is a kinase positioned within multiple obesity-related pathways, and prior work has shown a pathologic role of SGK1 signaling in ventricular arrhythmias. We validated a mouse model of obesity-related AF using wild-type mice fed a high-fat diet. RNA sequencing of atrial tissue demonstrated substantial differences in gene expression, with enrichment of multiple SGK1-related pathways, and we showed upregulated of SGK1 transcription, activation, and signaling in obese atria. Mice expressing a cardiac specific dominant-negative SGK1 were protected from obesity-related AF, through effects on atrial electrophysiology, action potential characteristics, structural remodeling, inflammation, and sodium current. Overall, this study demonstrates the promise of targeting SGK1 in a mouse model of obesity-related AF.","journal":"JCI Insight","year":2022,"id":257775,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9596,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":251867,"name":"Guoping Li","orcid":"0000-0003-3874-0744","position":1,"is_corresponding":false},{"id":849294,"name":"Ling Xiao","orcid":"0000-0002-5463-5576","position":2,"is_corresponding":false},{"id":253232,"name":"Ashish Yeri","orcid":null,"position":3,"is_corresponding":false},{"id":271228,"name":"Maarten Hulsmans","orcid":"0000-0003-1009-658X","position":4,"is_corresponding":false},{"id":642006,"name":"Jana Grune","orcid":"0000-0001-6209-7416","position":5,"is_corresponding":false},{"id":808360,"name":"Masahiro Yamazoe","orcid":null,"position":6,"is_corresponding":false},{"id":271217,"name":"Maximilian J. Schloss","orcid":"0009-0007-4979-690X","position":7,"is_corresponding":false},{"id":271225,"name":"Yoshiko Iwamoto","orcid":"0000-0002-3723-1043","position":8,"is_corresponding":false},{"id":908747,"name":"Justin Tedeschi","orcid":null,"position":9,"is_corresponding":false},{"id":908303,"name":"Xinyu Yang","orcid":"0009-0002-6036-8942","position":10,"is_corresponding":false},{"id":248977,"name":"Matthias Nahrendorf","orcid":"0000-0002-4021-1887","position":11,"is_corresponding":false},{"id":294916,"name":"Anthony Rosenzweig","orcid":"0000-0001-6387-0386","position":12,"is_corresponding":false},{"id":896,"name":"Patrick T. Ellinor","orcid":"0000-0002-2067-0533","position":13,"is_corresponding":false},{"id":251878,"name":"Saumya Das","orcid":"0000-0002-4521-4606","position":14,"is_corresponding":false},{"id":53944,"name":"David J. Milan","orcid":"0000-0003-0149-3110","position":15,"is_corresponding":false},{"id":908302,"name":"Aneesh Bapat","orcid":"0000-0002-1996-522X","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":null,"created_at":"2026-07-19T00:25:34.440699Z","pmid":"35998035","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}