{"doi":"10.1172/jci.insight.159090","title":"Combination therapy with remdesivir and monoclonal antibodies protects nonhuman primates against advanced Sudan virus disease","abstract":"A major challenge in managing acute viral infections is ameliorating disease when treatment is delayed. Previously, we reported the success of a 2-pronged mAb and antiviral remdesivir therapeutic approach to treat advanced illness in rhesus monkeys infected with Marburg virus (MARV). Here, we explored the benefit of a similar combination therapy for Sudan ebolavirus (Sudan virus; SUDV) infection. Importantly, no licensed anti-SUDV therapeutics currently exist, and infection of rhesus macaques with SUDV results in a rapid disease course similar to MARV with a mean time to death of 8.3 days. When initiation of therapy with either remdesivir or a pan-ebolavirus mAb cocktail (MBP431) was delayed until 6 days after inoculation, only 20% of macaques survived. In contrast, when remdesivir and MBP431 treatment were combined beginning 6 days after inoculation, significant protection (80%) was achieved. Our results suggest that combination therapy may be a viable treatment for patients with advanced filovirus disease that warrants further clinical testing in future outbreaks.","journal":"JCI Insight","year":2022,"id":240668,"datarank":0.5742962094733643,"base_score":3.828641396489095,"endowment":3.828641396489095,"self_citation_contribution":0.5742962094733643,"citation_network_contribution":0.0,"self_endowment_contribution":0.5742962094733643,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":279512,"name":"Zachary A. Bornholdt","orcid":"0000-0002-7557-9219","position":1,"is_corresponding":false},{"id":242844,"name":"Abhishek N. Prasad","orcid":"0000-0002-4147-2077","position":2,"is_corresponding":false},{"id":242843,"name":"Courtney Woolsey","orcid":"0000-0003-3389-0137","position":3,"is_corresponding":false},{"id":124945,"name":"Viktoriya Borisevich","orcid":null,"position":4,"is_corresponding":false},{"id":242845,"name":"Krystle N. Agans","orcid":"0000-0002-7319-6935","position":5,"is_corresponding":false},{"id":242846,"name":"Daniel J. Deer","orcid":"0009-0005-4744-8560","position":6,"is_corresponding":false},{"id":325138,"name":"Dafna M. Abelson","orcid":"0000-0003-4627-6902","position":7,"is_corresponding":false},{"id":639914,"name":"Do H. Kim","orcid":"0000-0003-3389-2618","position":8,"is_corresponding":false},{"id":641149,"name":"William S. Shestowsky","orcid":null,"position":9,"is_corresponding":false},{"id":410246,"name":"Lioudmila A. Campbell","orcid":null,"position":10,"is_corresponding":false},{"id":639915,"name":"Elaine Bunyan","orcid":"0000-0002-8743-1879","position":11,"is_corresponding":false},{"id":244154,"name":"Joan B. Geisbert","orcid":null,"position":12,"is_corresponding":false},{"id":242847,"name":"Natalie S. Dobias","orcid":"0009-0000-7352-5885","position":13,"is_corresponding":false},{"id":242851,"name":"Karla A. Fenton","orcid":"0000-0002-5530-6969","position":14,"is_corresponding":false},{"id":105122,"name":"Danielle Porter","orcid":"0000-0001-8459-2370","position":15,"is_corresponding":false},{"id":325141,"name":"Larry Zeitlin","orcid":"0000-0002-6857-1024","position":16,"is_corresponding":false},{"id":242852,"name":"Thomas W. Geisbert","orcid":"0000-0003-0858-1877","position":17,"is_corresponding":false},{"id":242853,"name":"Robert W. Cross","orcid":"0000-0001-7718-1522","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:22:51.435773Z","pmid":"35413016","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}