{"doi":"10.1172/jci.insight.158126","title":"T cell response to intact SARS-CoV-2 includes coronavirus cross-reactive and variant-specific components","abstract":"SARS-CoV-2 provokes a robust T cell response. Peptide-based studies exclude antigen processing and presentation biology, which may influence T cell detection studies. To focus on responses to whole virus and complex antigens, we used intact SARS-CoV-2 and full-length proteins with DCs to activate CD8 and CD4 T cells from convalescent people. T cell receptor (TCR) sequencing showed partial repertoire preservation after expansion. Resultant CD8 T cells recognize SARS-CoV-2-infected respiratory tract cells, and CD4 T cells detect inactivated whole viral antigen. Specificity scans with proteome-covering protein/peptide arrays show that CD8 T cells are oligospecific per subject and that CD4 T cell breadth is higher. Some CD4 T cell lines enriched using SARS-CoV-2 cross-recognize whole seasonal coronavirus (sCoV) antigens, with protein, peptide, and HLA restriction validation. Conversely, recognition of some epitopes is eliminated for SARS-CoV-2 variants, including spike (S) epitopes in the Alpha, Beta, Gamma, and Delta variant lineages.","journal":"JCI Insight","year":2022,"id":268775,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9655,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":587044,"name":"Xia Wu","orcid":"0000-0002-0024-4481","position":1,"is_corresponding":false},{"id":686924,"name":"Maxwell P. Krist","orcid":"0000-0002-4359-0851","position":2,"is_corresponding":false},{"id":245056,"name":"Tien-Ying Hsiang","orcid":"0000-0002-4316-4561","position":3,"is_corresponding":false},{"id":294663,"name":"Victoria Campbell","orcid":"0000-0001-6490-5974","position":4,"is_corresponding":false},{"id":294664,"name":"Christopher L. McClurkan","orcid":"0009-0008-0473-4366","position":5,"is_corresponding":false},{"id":930959,"name":"Sydney M. Favors","orcid":"0000-0003-2192-6016","position":6,"is_corresponding":false},{"id":931515,"name":"Lawrence A. Hemingway","orcid":null,"position":7,"is_corresponding":false},{"id":403350,"name":"Charmie Godornes","orcid":null,"position":8,"is_corresponding":false},{"id":931516,"name":"Denise Q. Tong","orcid":null,"position":9,"is_corresponding":false},{"id":296619,"name":"Stacy Selke","orcid":null,"position":10,"is_corresponding":false},{"id":931517,"name":"Angela LeClair","orcid":null,"position":11,"is_corresponding":false},{"id":830557,"name":"Chu-Woo Pyo","orcid":null,"position":12,"is_corresponding":false},{"id":387388,"name":"Daniel E. Geraghty","orcid":"0000-0001-7702-5650","position":13,"is_corresponding":false},{"id":430028,"name":"Kerry J. Laing","orcid":"0000-0001-9245-5325","position":14,"is_corresponding":false},{"id":294671,"name":"Anna Wald","orcid":"0000-0003-3486-6438","position":15,"is_corresponding":false},{"id":108916,"name":"Michael Gale","orcid":"0000-0002-6332-7436","position":16,"is_corresponding":false},{"id":294672,"name":"David M. Koelle","orcid":"0000-0003-1255-9023","position":17,"is_corresponding":false},{"id":294665,"name":"Lichen Jing","orcid":"0000-0002-5938-4171","position":0,"is_corresponding":true}],"reference_count":108,"raw_metadata":null,"created_at":"2026-07-19T00:27:14.088663Z","pmid":"35133988","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}