{"doi":"10.1172/jci.insight.152886","title":"NLRC4-mediated activation of CD1c+ DC contributes to perpetuation of synovitis in rheumatoid arthritis","abstract":"The individual contribution of specific myeloid subsets such as CD1c+ conventional DC (cDC) to perpetuation of rheumatoid arthritis (RA) pathology remains unclear. In addition, the specific innate sensors driving pathogenic activation of CD1c+ cDC in patients with RA and their functional implications have not been characterized. Here, we assessed phenotypical, transcriptional, and functional characteristics of CD1c+ and CD141+ cDC and monocytes from the blood and synovial fluid of patients with RA. Increased levels of CCR2 and the IgG receptor CD64 on circulating CD1c+ cDC was associated with the presence of this DC subset in the synovial membrane in patients with RA. Moreover, synovial CD1c+ cDC are characterized by increased expression of proinflammatory cytokines and high abilities to induce pathogenic IFN-γ+IL-17+CD4+ T cells in vitro. Finally, we identified the crosstalk between Fcγ receptors and NLRC4 as a potential molecular mechanism mediating pathogenic activation, CD64 upregulation, and functional specialization of CD1c+ cDC in response to dsDNA-IgG in patients with RA.","journal":"JCI Insight","year":2022,"id":260252,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":747136,"name":"Marta Calvet‐Mirabent","orcid":"0000-0002-9134-0849","position":1,"is_corresponding":false},{"id":913435,"name":"Ana Triguero‐Martínez","orcid":"0000-0003-1580-2893","position":2,"is_corresponding":false},{"id":913436,"name":"Enrique Vázquez","orcid":"0000-0003-1157-2592","position":3,"is_corresponding":false},{"id":913437,"name":"Alberto Benguría","orcid":"0000-0002-5536-566X","position":4,"is_corresponding":false},{"id":868892,"name":"Raquel Largo","orcid":"0000-0001-6525-2944","position":5,"is_corresponding":false},{"id":913438,"name":"Diego Calzada‐Fraile","orcid":"0000-0001-7259-0757","position":6,"is_corresponding":false},{"id":913439,"name":"O. V. Popova","orcid":"0009-0002-3749-588X","position":7,"is_corresponding":false},{"id":244375,"name":"Ildefonso Sánchez‐Cerrillo","orcid":"0000-0001-7262-1234","position":8,"is_corresponding":false},{"id":913440,"name":"Ilya Tsukalov","orcid":"0000-0002-2162-917X","position":9,"is_corresponding":false},{"id":913441,"name":"Roberto Moreno‐Vellisca","orcid":"0000-0002-9314-0998","position":10,"is_corresponding":false},{"id":244387,"name":"Hortensia de la Fuente","orcid":"0000-0001-8708-753X","position":11,"is_corresponding":false},{"id":913442,"name":"Gabriel Herrero‐Beaumont","orcid":"0000-0002-3241-991X","position":12,"is_corresponding":false},{"id":355623,"name":"Almudena R. Ramiro","orcid":"0000-0002-7539-3844","position":13,"is_corresponding":false},{"id":244391,"name":"Francisco Sánchez‐Madrid","orcid":"0000-0001-5303-0762","position":14,"is_corresponding":false},{"id":751158,"name":"Santos Castañeda","orcid":"0000-0002-7748-853X","position":15,"is_corresponding":false},{"id":913443,"name":"Ana Dopazo","orcid":"0000-0002-4910-1684","position":16,"is_corresponding":false},{"id":244389,"name":"Isidoro González‐Álvaro","orcid":"0000-0001-9614-5199","position":17,"is_corresponding":false},{"id":244393,"name":"Enrique Martín‐Gayo","orcid":"0000-0002-2619-6086","position":18,"is_corresponding":false},{"id":474400,"name":"Cristina Delgado‐Arévalo","orcid":null,"position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":null,"created_at":"2026-07-19T00:26:03.189798Z","pmid":"36194479","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}