{"doi":"10.1172/jci.insight.143174","title":"Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models","abstract":"We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human COVID-19 clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies to help guide decisions. Here we assessed the prophylactic/therapeutic efficacy of hydroxychloroquine (HCQ), a drug of interest for COVID-19 management, in 2 animal disease models. The standard human malaria HCQ prophylaxis (6.5 mg/kg given weekly) and treatment (6.5 mg/kg given daily) did not significantly benefit clinical outcome, nor did it reduce SARS-CoV-2 replication/shedding in the upper and lower respiratory tract in the rhesus macaque disease model. Similarly, when used for prophylaxis or treatment, neither the standard human malaria dose (6.5 mg/kg) nor a high dose (50 mg/kg) of HCQ had any beneficial effect on clinical disease or SARS-CoV-2 kinetics (replication/shedding) in the Syrian hamster disease model. Results from these 2 preclinical animal models may prove helpful in guiding clinical use of HCQ for prophylaxis/treatment of COVID-19.","journal":"JCI Insight","year":2020,"id":63848,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9604,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237976,"name":"Michael A. Jarvis","orcid":"0000-0002-0124-4061","position":1,"is_corresponding":false},{"id":107169,"name":"Friederike Feldmann","orcid":"0000-0002-1363-1077","position":2,"is_corresponding":false},{"id":108651,"name":"Benjamin Schwarz","orcid":"0000-0002-5894-953X","position":3,"is_corresponding":false},{"id":107174,"name":"Atsushi Okumura","orcid":"0000-0002-7779-3059","position":4,"is_corresponding":false},{"id":107189,"name":"Jamie Lovaglio","orcid":"0000-0002-7567-446X","position":5,"is_corresponding":false},{"id":107192,"name":"Greg Saturday","orcid":"0000-0002-0803-6177","position":6,"is_corresponding":false},{"id":107190,"name":"Patrick W. Hanley","orcid":"0000-0003-2300-1818","position":7,"is_corresponding":false},{"id":107175,"name":"Kimberly Meade‐White","orcid":"0000-0003-0503-8174","position":8,"is_corresponding":false},{"id":107181,"name":"Brandi N. Williamson","orcid":"0000-0002-9524-4395","position":9,"is_corresponding":false},{"id":237972,"name":"Frederick Hansen","orcid":"0000-0003-3890-1915","position":10,"is_corresponding":false},{"id":107176,"name":"Lizzette Pérez-Pérez","orcid":"0000-0001-5881-4363","position":11,"is_corresponding":false},{"id":239425,"name":"Shanna Leventhal","orcid":null,"position":12,"is_corresponding":false},{"id":239244,"name":"Tsing-Lee Tang-Huau","orcid":null,"position":13,"is_corresponding":false},{"id":108408,"name":"Julie Callison","orcid":null,"position":14,"is_corresponding":false},{"id":274878,"name":"Elaine Haddock","orcid":"0000-0002-8260-227X","position":15,"is_corresponding":false},{"id":337612,"name":"Kaitlin A. Stromberg","orcid":"0000-0002-6005-2692","position":16,"is_corresponding":false},{"id":107191,"name":"Dana Scott","orcid":"0000-0002-7344-9402","position":17,"is_corresponding":false},{"id":337613,"name":"Graham Sewell","orcid":"0000-0001-8856-3980","position":18,"is_corresponding":false},{"id":245763,"name":"Catharine M. Bosio","orcid":"0000-0002-7332-9611","position":19,"is_corresponding":false},{"id":238504,"name":"David W. Hawman","orcid":"0000-0001-8233-8176","position":20,"is_corresponding":false},{"id":106696,"name":"Emmie de Wit","orcid":"0000-0002-9763-7758","position":21,"is_corresponding":false},{"id":107426,"name":"Heinz Feldmann","orcid":"0000-0001-9448-8227","position":22,"is_corresponding":false},{"id":237970,"name":"Kyle Rosenke","orcid":"0000-0001-8101-4348","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T21:11:24.000992Z","pmid":"33090972","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}