{"doi":"10.1172/jci.insight.140644","title":"Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis","abstract":"Interleukin-10 (IL-10) is a critical cytokine used by immune cells to suppress inflammation. Paradoxically, immune cell-derived IL-10 can drive insulin resistance in obesity by suppressing adipocyte energy expenditure and thermogenesis. However, the source of IL-10 necessary for the suppression of adipocyte thermogenesis is unknown. We show here that CD4+Foxp3+ regulatory T cells (Tregs) are a substantial source of IL-10 and that Treg-derived IL-10 can suppress adipocyte beiging. Unexpectedly, Treg-specific loss of IL-10 resulted in increased insulin sensitivity and reduced obesity in high-fat diet-fed male mice. Mechanistically, we determined that Treg-specific loss of the transcription factor Blimp-1, a driver of IL-10 expression by Tregs, phenocopied the Treg-specific IL-10-deficient mice. Loss of Blimp-1 expression in Tregs resulted in reduced ST2+KLRG1+, IL-10-secreting Tregs, particularly in the white adipose tissue. Blimp-1-deficient mice were protected from glucose intolerance, insulin resistance, and diet-induced obesity, through increased white adipose tissue browning. Taken together, our data show that Blimp-1-regulated IL-10 secretion by Tregs represses white adipose tissue beiging to maintain adipose tissue homeostasis.","journal":"JCI Insight","year":2020,"id":54805,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":100,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9461,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":283643,"name":"Raja Gopal Reddy Mooli","orcid":null,"position":1,"is_corresponding":false},{"id":283644,"name":"Xiaoyao Qu","orcid":null,"position":2,"is_corresponding":false},{"id":282222,"name":"Giovanni Marrero","orcid":"0000-0003-1587-3624","position":3,"is_corresponding":false},{"id":283645,"name":"Christopher Finley","orcid":null,"position":4,"is_corresponding":false},{"id":282223,"name":"Allen Fooks","orcid":"0000-0003-3999-0438","position":5,"is_corresponding":false},{"id":283646,"name":"Zachary P. Mullen","orcid":null,"position":6,"is_corresponding":false},{"id":282224,"name":"Adolfo B. Frias","orcid":"0000-0001-5768-3568","position":7,"is_corresponding":false},{"id":283647,"name":"Ian Sipula","orcid":null,"position":8,"is_corresponding":false},{"id":282225,"name":"Bingxian Xie","orcid":"0000-0001-9816-2670","position":9,"is_corresponding":false},{"id":283648,"name":"Katherine Helfrich","orcid":null,"position":10,"is_corresponding":false},{"id":279286,"name":"Simon C. Watkins","orcid":"0000-0003-4092-1552","position":11,"is_corresponding":false},{"id":282226,"name":"Amanda C. Poholek","orcid":"0000-0002-5587-8940","position":12,"is_corresponding":false},{"id":282227,"name":"Sadeesh K. Ramakrishnan","orcid":"0000-0002-7255-2977","position":13,"is_corresponding":false},{"id":237077,"name":"Michael J. Jurczak","orcid":"0000-0002-6335-6915","position":14,"is_corresponding":false},{"id":282228,"name":"Louise M. D’Cruz","orcid":"0000-0003-0388-430X","position":15,"is_corresponding":false},{"id":282221,"name":"Lisa Beppu","orcid":"0000-0002-6918-1159","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T21:04:14.743014Z","pmid":"33351782","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}