{"doi":"10.1172/jci.insight.135751","title":"Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells","abstract":"Extramedullary hematopoietic cells are present in the liver of normal neonates in the first few days of life and persist in infants with biliary atresia. Based on a previous report that liver genes are enriched by erythroid pathways, we examined the liver gene expression pattern at diagnosis and found the top 5 enriched pathways are related to erythrocyte pathobiology in children who survived with the native liver beyond 2 years of age. Using immunostaining, anti-CD71 antibodies identified CD71+ erythroid cells among extramedullary hematopoietic cells in the livers at the time of diagnosis. In mechanistic experiments, the preemptive antibody depletion of hepatic CD71+ erythroid cells in neonatal mice rendered them resistant to rhesus rotavirus-induced (RRV-induced) biliary atresia. The depletion of CD71+ erythroid cells increased the number of effector lymphocytes and delayed the RRV infection of livers and extrahepatic bile ducts. In coculture experiments, CD71+ erythroid cells suppressed the activation of hepatic mononuclear cells. These data uncover an immunoregulatory role for CD71+ erythroid cells in the neonatal liver.","journal":"JCI Insight","year":2020,"id":77971,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9453,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":406192,"name":"Pranavkumar Shivakumar","orcid":"0000-0002-2095-0623","position":1,"is_corresponding":false},{"id":406193,"name":"Jeremy M. Kinder","orcid":"0000-0001-5145-1344","position":2,"is_corresponding":false},{"id":270438,"name":"Sing Sing Way","orcid":"0000-0001-8948-1952","position":3,"is_corresponding":false},{"id":286798,"name":"Bryan Donnelly","orcid":null,"position":4,"is_corresponding":false},{"id":406194,"name":"Reena Mourya","orcid":"0000-0003-4525-0196","position":5,"is_corresponding":false},{"id":406195,"name":"Zhenhua Luo","orcid":"0000-0002-6516-8555","position":6,"is_corresponding":false},{"id":406196,"name":"Jorge A. Bezerra","orcid":"0000-0001-9667-7742","position":7,"is_corresponding":false},{"id":337861,"name":"Li Yang","orcid":"0000-0002-3228-2140","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T21:49:40.769098Z","pmid":"32407296","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}