{"doi":"10.1172/jci.insight.130655","title":"Serine/threonine phosphatase PP2A is essential for optimal B cell function","abstract":"Protein phosphatase 2A (PP2A), a serine/threonine phosphatase, has been shown to control T cell function. We found that in vitro-activated B cells and B cells from various lupus-prone mice and patients with systemic lupus erythematosus display increased PP2A activity. To understand the contribution of PP2A to B cell function, we generated a Cd19CrePpp2r1afl/fl (flox/flox) mouse which lacks functional PP2A only in B cells. Flox/flox mice displayed reduced spontaneous germinal center formation and decreased responses to T cell-dependent and T-independent antigens, while their B cells responded poorly in vitro to stimulation with an anti-CD40 antibody or CpG in the presence of IL-4. Transcriptome and metabolome studies revealed altered nicotinamide adenine dinucleotide (NAD) and purine/pyrimidine metabolism and increased expression of purine nucleoside phosphorylase in PP2A-deficient B cells. Our results demonstrate that PP2A is required for optimal B cell function and may contribute to increased B cell activity in systemic autoimmunity.","journal":"JCI Insight","year":2020,"id":77827,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":281382,"name":"Hao Li","orcid":"0000-0002-2171-8826","position":1,"is_corresponding":false},{"id":387834,"name":"Wenliang Pan","orcid":"0009-0003-5965-2126","position":2,"is_corresponding":false},{"id":405081,"name":"Michihito Kono","orcid":"0000-0002-7663-534X","position":3,"is_corresponding":false},{"id":405082,"name":"Shuilian Yu","orcid":"0000-0002-0739-1441","position":4,"is_corresponding":false},{"id":255851,"name":"Vasileios C. Kyttaris","orcid":"0000-0001-7652-3826","position":5,"is_corresponding":false},{"id":405966,"name":"Christina Ioannidis","orcid":null,"position":6,"is_corresponding":false},{"id":339076,"name":"Noé Rodríguez‐Rodríguez","orcid":"0000-0001-7825-5634","position":7,"is_corresponding":false},{"id":339078,"name":"José C. Crispín","orcid":"0000-0002-7590-3621","position":8,"is_corresponding":false},{"id":105477,"name":"Sokratis A. Apostolidis","orcid":"0000-0002-0224-0097","position":9,"is_corresponding":false},{"id":230129,"name":"Pui Y. Lee","orcid":"0000-0002-5779-4193","position":10,"is_corresponding":false},{"id":405083,"name":"John Manis","orcid":"0000-0002-3630-778X","position":11,"is_corresponding":false},{"id":281387,"name":"Amir Sharabi","orcid":"0000-0002-6242-6774","position":12,"is_corresponding":false},{"id":281388,"name":"Maria Tsokos","orcid":"0000-0001-8072-1358","position":13,"is_corresponding":false},{"id":12823,"name":"George C. Tsokos","orcid":"0000-0001-9589-2360","position":14,"is_corresponding":false},{"id":233970,"name":"Esra Meidan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T21:49:16.197289Z","pmid":"32161189","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}