{"doi":"10.1167/tvst.14.9.10","title":"Three-Dimensional Choroidal Vessels Assessment in Fellow Eyes of Patients With Central Serous Chorioretinopathy","abstract":"Purpose: To evaluate choroidal vasculature using a novel three-dimensional algorithm in fellow eyes of patients with unilateral chronic central serous chorioretinopathy (cCSC). Methods: Patients with unilateral cCSC were retrospectively included. Automated choroidal segmentation was conducted using a deep-learning ResUNet model. Phansalkar thresholding was applied to binarize choroidal vasculature, and three-dimensional maps were created. Mean choroidal vessel diameter, intervessel distance, choroidal thickness, and choroidal vascularity index (CVI) were measured. Linear mixed models were used for statistical analysis. Results: Thirty unilateral cCSC eyes, 22 fellow, and 26 controls were included. Both cCSC and fellow eyes exhibited significant higher mean choroidal vessel diameter compared with controls (362.50 ± 83.23 µm, 276.84 ± 26.89 µm, and 233.28 ± 28.18 µm, respectively; P < 0.001), and in choroidal thickness (288.90 ± 64.77 µm, 269.76 ± 71.17 µm, and 223.97 ± 43.40 µm, respectively; P = 0.001). The intervessel distance was reduced in cCSC and fellow eyes compared with controls (196.53 ± 23.58 µm, 225.05 ± 33.72 µm, and 264.13 ± 46.06 µm, respectively; P < 0.001). Although lower, the CVI was not significantly different in cCSC and fellow eyes compared with controls (38.14 ± 5.55%, 37.23 ± 6.41%, and 40.65 ± 3.53%, respectively; P = 0.066), indicating a possible trend toward a lower CVI. Conclusions: Three-dimensional representation of choroidal vasculature revealed significant changes in both cCSC and fellow eyes, including a larger diameter and reduced spacing compared with healthy controls. Translational Relevance: Using a validated deep learning-based three-dimensional method, we observed changes in the choroidal vasculature in both CSC and fellow eyes.","journal":"Translational Vision Science & Technology","year":2025,"id":524392,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9651,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1237531,"name":"Elham Sadeghi","orcid":"0000-0003-3802-3219","position":1,"is_corresponding":false},{"id":1237964,"name":"Elli Davis","orcid":null,"position":2,"is_corresponding":false},{"id":879989,"name":"Mohammed Nasar Ibrahim","orcid":"0000-0002-6560-3481","position":3,"is_corresponding":false},{"id":1380688,"name":"Nasiq Hasan","orcid":"0000-0001-6296-8023","position":4,"is_corresponding":false},{"id":893255,"name":"Sandeep Chandra Bollepalli","orcid":"0000-0002-9971-9335","position":5,"is_corresponding":false},{"id":528696,"name":"Sumit Randhir Singh","orcid":"0000-0001-8932-5343","position":6,"is_corresponding":false},{"id":1380689,"name":"Luigi Fontana","orcid":"0000-0003-3877-0417","position":7,"is_corresponding":false},{"id":54623,"name":"José‐Alain Sahel","orcid":"0000-0002-4831-1153","position":8,"is_corresponding":false},{"id":879991,"name":"Kiran Kumar Vupparaboina","orcid":"0000-0003-0024-8404","position":9,"is_corresponding":false},{"id":393397,"name":"Jay Chhablani","orcid":"0000-0003-1772-3558","position":10,"is_corresponding":false},{"id":1237532,"name":"Nicola Valsecchi","orcid":"0000-0002-3887-7655","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T02:50:12.083054Z","pmid":"40919871","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}