{"doi":"10.1167/tvst.14.2.12","title":"Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study","abstract":"Purpose: A cross-sectional pilot study to compare macular oxygen saturation (sO2) and associated clinical measurements between normal and glaucoma subjects and to evaluate whether macular sO2 can be a diagnostic metric for early-stage glaucoma. Methods: Forty-eight eyes of 35 subjects from three groups were included: normal subjects (16 eyes, 10 subjects), suspect/pre-perimetric glaucoma (GS/PPG) subjects (17 eyes, 12 subjects), and perimetric glaucoma (PG) subjects (15 eyes, 13 subjects). We performed retinal oximetry of visible light optical coherence tomography (VIS-OCT) in macular vessels, with 512 × 256 sampling points over a 5 × 5 mm2 area. Zeiss Cirrus OCT scans and a 24-2 visual field test (VFT) were conducted. Statistical analysis was conducted. Results: Significant differences were observed among the three groups for all VIS-OCT, Zeiss OCT, and VFT variables. As glaucoma severity increased, macular AsO2 (arterial sO2) and A-V sO2 (arteriovenous sO2 difference) decreased, whereas macular VsO2 (venous sO2) increased. Macular AsO2 and A-V sO2 were found to be statistically correlated with ganglion cell layer + inner plexiform layer (GCL+IPL) and circumpapillary retinal nerve fiber layer in all eyes, as well as in PG eyes. Within the PG group, a dominant correlation between AsO2 and ganglion cell layer + inner plexiform layer was observed in the more damaged lower hemifield. Conclusions: Glaucoma subjects showed altered macular sO2, indicating reduced oxygen consumption. The sO2 measured by VIS-OCT could be a potential metric for early glaucoma diagnosis. Translational Relevance: This study shows macular sO2 measurements via VIS-OCT could bridge advanced imaging technology and clinical glaucoma detection.","journal":"Translational Vision Science & Technology","year":2025,"id":537953,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9023,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1168749,"name":"Natalie Sadlak","orcid":null,"position":1,"is_corresponding":false},{"id":664457,"name":"Marissa G. Fiorello","orcid":"0000-0003-2357-2258","position":2,"is_corresponding":false},{"id":323162,"name":"Manishi Desai","orcid":"0000-0003-2391-6372","position":3,"is_corresponding":false},{"id":323164,"name":"Ji Yi","orcid":"0000-0001-6583-7192","position":4,"is_corresponding":false},{"id":970158,"name":"Jingyu Wang","orcid":"0000-0002-1614-4426","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T02:52:16.891390Z","pmid":"39913123","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}