{"doi":"10.1167/tvst.14.11.23","title":"Three-Dimensional Choroidal Contour Mapping in Central Serous Chorioretinopathy and Fellow Eyes","abstract":"Purpose: Quantitative evaluation of three-dimensional (3D) choroidal contour at choroidal inner boundary (CIB) and choroidal outer boundary (COB) in central serous chorioretinopathy (CSCR) and fellow eyes of patients with unilateral CSCR. Methods: Retrospective study on 58 eyes of 29 patients with unilateral CSCR. Detailed examination and investigations including wide-field swept source optical coherence tomography (SS-OCT) were performed. Delineation of CIB and COB was performed using a hybrid method based on our previously validated deep learning and 3D smoothing methods for choroidal layer segmentation. Quantitative analysis of the surfaces was based on best-fit spherical radius (R). Statistical analysis was done using SPSS software. Results: R CIB and R COB was significantly higher in CSCR eyes compared to fellow eyes (P = 0.001, 0.02). On sectoral analysis, central sector had the lowest R compared to all the other sectors in CSCR eyes (P < 0.001) and fellow eyes (P < 0.001). Within the group, R CIB > R COB in CSCR eyes (P = 0.001) and in fellow eyes (P = 0.014), and there was a high degree of correlation between RCIB and RCOB within a group (CSCR: r = 0.88, P < 0.001; fellow eyes: r = 0.87, P < 0.001). Conclusions: This study shows CIB and COB to be flatter in CSCR eyes compared to fellow eyes. In both CSCR and fellow eyes, CIB is flatter than COB. Translational Relevance: Studying choroidal surfaces helps understand how predispositions and compensatory mechanisms to venous overloading may differ in CSCR and fellow eyes and how contour changes may serve as a biomarker for the disease.","journal":"Translational Vision Science & Technology","year":2025,"id":581560,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7765,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":528696,"name":"Sumit Randhir Singh","orcid":"0000-0001-8932-5343","position":1,"is_corresponding":false},{"id":1237531,"name":"Elham Sadeghi","orcid":"0000-0003-3802-3219","position":2,"is_corresponding":false},{"id":1493176,"name":"Priyanka Gandhi","orcid":"0000-0002-9641-2450","position":3,"is_corresponding":false},{"id":1451059,"name":"Anne Schulman","orcid":null,"position":4,"is_corresponding":false},{"id":879989,"name":"Mohammed Nasar Ibrahim","orcid":"0000-0002-6560-3481","position":5,"is_corresponding":false},{"id":893255,"name":"Sandeep Chandra Bollepalli","orcid":"0000-0002-9971-9335","position":6,"is_corresponding":false},{"id":879991,"name":"Kiran Kumar Vupparaboina","orcid":"0000-0003-0024-8404","position":7,"is_corresponding":false},{"id":54623,"name":"José‐Alain Sahel","orcid":"0000-0002-4831-1153","position":8,"is_corresponding":false},{"id":393397,"name":"Jay Chhablani","orcid":"0000-0003-1772-3558","position":9,"is_corresponding":false},{"id":1060936,"name":"Supriya Arora","orcid":"0000-0002-1992-0822","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:58:51.328454Z","pmid":"41251531","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}