{"doi":"10.1167/tvst.14.1.16","title":"High-Resolution OCT Reveals Age-Associated Variation in the Region Posterior to the External Limiting Membrane","abstract":"Purpose: To evaluate visibility of a sub-band posterior to the external limiting membrane (ELM) and assess its age-associated variation. Methods: In a retrospective cross-sectional study, normal eyes were imaged using a high-resolution spectral-domain optical coherence tomography (SD-OCT) prototype (2.7-µm axial resolution). Volume fusion of six sequential scans (each 500 × 500 A-scans over 6 mm × 6 mm) was performed in the motion correction and volume reconstruction in OCT (MoReOCT) framework to enhance feature visibility in OCT. The subjects were divided into three groups: young (21-40 years old), middle (41-60 years old), and older (>60 years old). Three expert graders assessed the visibility of the sub-band on B-scans, and its A-scan intensity relative to ELM intensity (peak intensity ratio) was measured. Results: Forty-four eyes of 44 subjects were imaged. The sub-band, tentatively attributed to the photoreceptor myoid, can be visualized under high-resolution OCT. The B-scan gradings showed that sub-band visibility increased with age (visible in 16.7%, 47.2%, and 66.7% of the young, middle, and older age groups, respectively). The gradings were statistically different among age groups at 1 mm and 2 mm nasal and 1 mm and 2 mm temporal (P < 0.04) from the foveal center. Similarly, the mean peak intensity ratios of the sub-band to the ELM were 71.6%, 77.5%, and 85.2% in the young, middle, and older age groups, respectively, and were positively correlated with age at 1 mm temporal (P = 0.012) and 2 mm temporal (P < 0.001). Conclusions: High-resolution OCT, combined with advanced volume fusion, enables visualization of the photoreceptor myoid and investigation of its age-associated variations. Translational Relevance: Investigating the sub-band can advance our understanding of photoreceptors and their association with aging and disease pathogenesis.","journal":"Translational Vision Science & Technology","year":2025,"id":525157,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7064,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":388830,"name":"Jungeun Won","orcid":"0000-0003-1007-4049","position":1,"is_corresponding":false},{"id":371295,"name":"Stefan B. 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Zhao","orcid":"0000-0003-1430-1034","position":10,"is_corresponding":false},{"id":1399975,"name":"Shilpa Desai","orcid":null,"position":11,"is_corresponding":false},{"id":341666,"name":"Jay S. Duker","orcid":"0000-0002-5482-4844","position":12,"is_corresponding":false},{"id":227226,"name":"Andreas Maier","orcid":"0000-0002-9550-5284","position":13,"is_corresponding":false},{"id":85587,"name":"James G. Fujimoto","orcid":"0000-0002-0828-4357","position":14,"is_corresponding":false},{"id":326978,"name":"Nadia K. Waheed","orcid":"0000-0002-8229-7519","position":15,"is_corresponding":false},{"id":1273183,"name":"Muhammad Usman Jamil","orcid":"0000-0001-9642-1886","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:50:16.562292Z","pmid":"39813051","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}