{"doi":"10.1167/iovs.66.15.45","title":"Association of Mesopic and Dark-Adapted Retinal Sensitivity With Type 1 Macular Neovascularization in Age-Related Macular Degeneration","abstract":"Purpose: To assess the impact of type 1 macular neovascularization (MNV) on mesopic and dark-adapted (DA) cyan retinal sensitivity using fundus-controlled perimetry (FCP [microperimetry]) in patients with age-related macular degeneration (AMD). Methods: This index study includes baseline data from AMD patients with type 1 MNV without complete retinal pigment epithelium and outer retinal atrophy (cRORA). Mesopic and DA-cyan sensitivity were measured using FCP with standardized and MNV-lesion-tailored test grids. We applied linear mixed-effects models to compare retinal sensitivity in regions with versus without co-localized type 1 MNV. Age-specific hill-of-vision data that served as reference were estimated using Bayesian quantile regressions. Results: Of the 55 eyes with baseline data, 27 eyes without cRORA (27 patients; mean age, 76.8 ± 6.7 years; 74.1% female) were included in this detailed analysis. In regions co-localizing with type 1 MNV, unadjusted mesopic sensitivity was significantly increased by a mean of 2.10 dB (95% confidence interval [CI], 1.58-2.63; P < 0.001), whereas unadjusted DA-cyan sensitivity was significantly reduced by 3.12 dB (95% CI, 2.38-3.86; P < 0.001) compared to regions without evidence of MNV. When adjusting for age-specific hill-of-vision reference data, mesopic sensitivity remained significantly higher by 0.78 dB (95% CI, 0.29-1.28; P = 0.002) and DA-cyan sensitivity remained significantly lower by 2.07 dB (95% CI, 1.33-2.80; P < 0.001) in regions co-localizing with type 1 MNV versus those without MNV. Conclusions: In AMD, areas overlying type 1 MNV showed higher mesopic but reduced DA-cyan sensitivity, suggesting localized preservation yet subtype-specific vulnerability. These findings will be further examined through structural analyses and prospective validation in our ongoing study.","journal":"Investigative Ophthalmology & Visual Science","year":2025,"id":585281,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10491,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7162,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1102299,"name":"Yingjia Wei","orcid":"0000-0001-7518-0163","position":1,"is_corresponding":false},{"id":1138804,"name":"Ray Nelson","orcid":null,"position":2,"is_corresponding":false},{"id":1499082,"name":"Sandrine H. Sassen","orcid":null,"position":3,"is_corresponding":false},{"id":1499083,"name":"Karen Daynes","orcid":null,"position":4,"is_corresponding":false},{"id":1455613,"name":"Fiona Clark","orcid":"0000-0003-2247-2490","position":5,"is_corresponding":false},{"id":1498644,"name":"Tyler Brown","orcid":"0000-0003-2759-8922","position":6,"is_corresponding":false},{"id":782174,"name":"Alyssa Messina","orcid":null,"position":7,"is_corresponding":false},{"id":263799,"name":"Maximilian Pfau","orcid":"0000-0001-9761-9640","position":8,"is_corresponding":false},{"id":1498645,"name":"Yue Zhang","orcid":"0000-0003-0365-7991","position":9,"is_corresponding":false},{"id":1004156,"name":"Steffen Schmitz‐Valckenberg","orcid":null,"position":10,"is_corresponding":false},{"id":263800,"name":"Monika Fleckenstein","orcid":"0000-0001-8321-8037","position":11,"is_corresponding":false},{"id":920779,"name":"Irmak Karaca","orcid":"0000-0001-7927-0887","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:59:20.067334Z","pmid":"41396449","pmcid":"PMC12710790","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}