{"doi":"10.1167/iovs.66.11.18","title":"Matrine Reduces Intraocular Pressure in Corticosteroid-Induced Ocular Hypertensive Mouse Eyes","abstract":"Purpose: This study investigates the potential of matrine, a quinolizidine alkaloid, in regulating intraocular pressure (IOP) in normal and corticosteroid-induced ocular hypertension (OHT) mice. Methods: Wild-type C57BL/6 mice were randomly divided into normal and OHT groups. The OHT mouse model was established by periocular conjunctival fornix injections of dexamethasone-21-acetate (DEX). IOP was measured at 0.0, 0.5, 1.0, 3.0, and 6.0 hours after matrine treatment in both groups. Aqueous humor (AH) outflow facility was measured using our previously described/validated perfusion system. Anterior segment-optical coherence tomography was used to evaluate morphological changes in the anterior chamber following matrine treatment. Hematoxylin and eosin staining and immunofluorescence staining were used to investigate structural changes. Results: Matrine treatment (50-200 µg/g) decreased the IOP in normal mice in a dose-dependent manner. AH outflow facility in normal mice elevated at 0.5 hours after matrine treatment (100 and 200 µg/g). Additionally, 100 µg/g matrine treatment increased the angle opening distance in the anterior chamber. In DEX-induced OHT mice, matrine (100 and 200 µg/g) reduced the elevated IOP and increased the AH outflow facility. Furthermore, 100 µg/g matrine treatment increased the angle opening distance compared with that of PBS-treated controls. However, matrine (100 µg/g) did not induce significant changes in trabecular meshwork gross morphology or the expression of cell contractility and extracellular matrix markers in OHT mice at 0.5 hours after treatment. Conclusions: Matrine decreased the IOP in the DEX-induced OHT mouse model, highlighting its potential as a therapeutic agent for managing glaucoma, particularly in corticosteroid-associated secondary cases.","journal":"Investigative Ophthalmology & Visual Science","year":2025,"id":545886,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9625,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1281393,"name":"Zhiquan Liu","orcid":"0000-0001-5433-5656","position":1,"is_corresponding":false},{"id":1300303,"name":"Siyu Chen","orcid":"0009-0004-9801-4917","position":2,"is_corresponding":false},{"id":694955,"name":"Qing Wang","orcid":"0009-0006-8194-5680","position":3,"is_corresponding":false},{"id":281722,"name":"Chien‐Hui Lo","orcid":"0000-0001-9016-0953","position":4,"is_corresponding":false},{"id":399499,"name":"Ke Ning","orcid":"0000-0001-8994-3803","position":5,"is_corresponding":false},{"id":1338118,"name":"Jingyu Zhao","orcid":"0009-0000-0989-6593","position":6,"is_corresponding":false},{"id":666097,"name":"Ying‐Chun Shen","orcid":"0000-0001-8426-9071","position":7,"is_corresponding":false},{"id":389827,"name":"Paloma B. Liton","orcid":"0000-0002-1440-3762","position":8,"is_corresponding":false},{"id":2816,"name":"Yang Sun","orcid":"0000-0002-9344-8060","position":9,"is_corresponding":false},{"id":1378156,"name":"Qí Zhāng","orcid":"0000-0001-6300-6491","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":null,"created_at":"2026-07-19T02:53:27.751050Z","pmid":"40772663","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}