{"doi":"10.1167/iovs.64.15.42","title":"The Impact of Carotid Endarterectomy on Choriocapillaris Perfusion","abstract":"Purpose: The impact of carotid endarterectomy (CEA) on choriocapillaris (CC) perfusion was investigated using swept-source optical coherence tomography angiography (SS-OCTA) imaging before and after surgery in patients with clinically significant carotid artery stenosis (CAS). Methods: In this prospective observational study, patients with clinically significant CAS undergoing unilateral CEA had SS-OCTA imaging performed in both eyes before and within 1 week after surgery. The percent CC flow deficits (CC FD%) and CC thickness were assessed using previously validated algorithms. Multivariable regression analysis was conducted to evaluate the impact of variables on the change in CC measurements. Results: A total of 112 eyes from 56 patients with an average age of 72.6 ± 6.9 years were enrolled. At baseline, significantly higher CC FD% and thinner CC thickness were observed on the surgical side (eyes ipsilateral to the side of CEA) versus the nonsurgical side (eyes contralateral to the side of CEA) (P = 0.001 and P = 0.03, respectively). Following CEA, a significant reduction in CC FD% and a significant increase in CC thickness were detected on the surgical as compared with the nonsurgical side (P = 0.008 and P = 0.01, respectively). Smoking status positively affected CC FD% change (coefficient of variation [CV] = 0.84, P = 0.01) on the surgical side and negatively affected CC thickness change on both the surgical side (CV = -0.382, P = 0.009) and the nonsurgical side (CV = -0.321, P = 0.04). The degree of stenosis demonstrated a positive influence on CC FD% change (CV = 0.040, P = 0.02) on the surgical side. Conclusions: Unilateral CEA on the side of clinically significant CAS increases carotid blood flow, which further results in improved CC perfusion.","journal":"Investigative Ophthalmology & Visual Science","year":2023,"id":330614,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1054840,"name":"Yi Zhang","orcid":"0009-0005-4678-7181","position":1,"is_corresponding":false},{"id":1055501,"name":"Natalie Noam","orcid":null,"position":2,"is_corresponding":false},{"id":1054841,"name":"David Rabinovitch","orcid":"0000-0003-4970-7747","position":3,"is_corresponding":false},{"id":1054842,"name":"D.A. Bar","orcid":"0000-0003-0216-8694","position":4,"is_corresponding":false},{"id":1054843,"name":"Basheer Sheick Yousif","orcid":"0000-0003-1810-9066","position":5,"is_corresponding":false},{"id":796084,"name":"Robert O’Brien","orcid":"0000-0002-3611-1648","position":6,"is_corresponding":false},{"id":1054844,"name":"Farhan E. Hiya","orcid":"0000-0003-4127-4211","position":7,"is_corresponding":false},{"id":1054845,"name":"Yufen Lin","orcid":"0009-0008-9655-5284","position":8,"is_corresponding":false},{"id":1054846,"name":"Alessandro Berni","orcid":"0000-0002-6412-1288","position":9,"is_corresponding":false},{"id":304780,"name":"Giovanni Gregori","orcid":"0000-0003-0951-2216","position":10,"is_corresponding":false},{"id":284472,"name":"Ruikang K. Wang","orcid":"0000-0001-5169-8822","position":11,"is_corresponding":false},{"id":304779,"name":"Philip J. Rosenfeld","orcid":"0000-0002-4068-6671","position":12,"is_corresponding":false},{"id":1054847,"name":"Omer Trivizki","orcid":"0000-0003-3887-6238","position":13,"is_corresponding":false},{"id":1055500,"name":"Sandy Wenting Zhou","orcid":null,"position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:09:14.691473Z","pmid":"38153750","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}