{"doi":"10.1165/rcmb.2024-0004oc","title":"Monocyte Production of C1q Potentiates CD8+ T-Cell Function Following Respiratory Viral Infection","abstract":"Abstract Respiratory viral infections remain a leading cause of morbidity and mortality. Using a murine model of human metapneumovirus, we identified recruitment of a C1q-expressing inflammatory monocyte population concomitant with viral clearance by adaptive immune cells. Genetic ablation of C1q led to reduced CD8+ T-cell function. Production of C1q by a myeloid lineage was necessary to enhance CD8+ T-cell function. Activated and dividing CD8+ T cells expressed a C1q receptor, gC1qR. Perturbation of gC1qR signaling led to altered CD8+ T-cell IFN-γ production, metabolic capacity, and cell proliferation. Autopsy specimens from fatal respiratory viral infections in children exhibited diffuse production of C1q by an interstitial population. Humans with severe coronavirus disease (COVID-19) infection also exhibited upregulation of gC1qR on activated and rapidly dividing CD8+ T cells. Collectively, these studies implicate C1q production from monocytes as a critical regulator of CD8+ T-cell function following respiratory viral infection.","journal":"American Journal of Respiratory Cell and Molecular Biology","year":2024,"id":463242,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":657355,"name":"Olivia B. Parks","orcid":"0000-0003-1131-9407","position":1,"is_corresponding":false},{"id":1187504,"name":"Dequan Lou","orcid":null,"position":2,"is_corresponding":false},{"id":818388,"name":"Li Fan","orcid":"0000-0002-8764-3687","position":3,"is_corresponding":false},{"id":879952,"name":"Jorna Sojati","orcid":"0000-0002-3908-6126","position":4,"is_corresponding":false},{"id":1187505,"name":"Manda Jo Ramsey","orcid":null,"position":5,"is_corresponding":false},{"id":489644,"name":"Lori Schmitt","orcid":null,"position":6,"is_corresponding":false},{"id":784927,"name":"Cláudia Salgado","orcid":"0000-0002-8821-1296","position":7,"is_corresponding":false},{"id":623648,"name":"Miguel Reyes‐Múgica","orcid":"0000-0001-5698-3702","position":8,"is_corresponding":false},{"id":1293448,"name":"Alysa N Evans","orcid":"0009-0003-0539-2701","position":9,"is_corresponding":false},{"id":1266869,"name":"Henry M. Zou","orcid":"0009-0005-8628-7827","position":10,"is_corresponding":false},{"id":315201,"name":"Tim D. Oury","orcid":"0000-0002-4253-3214","position":11,"is_corresponding":false},{"id":475624,"name":"Craig A. Byersdorfer","orcid":"0000-0002-0030-3699","position":12,"is_corresponding":false},{"id":279535,"name":"Kong Chen","orcid":"0000-0001-6980-5454","position":13,"is_corresponding":false},{"id":236968,"name":"John V. Williams","orcid":"0000-0001-8377-5175","position":14,"is_corresponding":false},{"id":780746,"name":"Taylor Eddens","orcid":"0000-0003-2969-3624","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T02:04:28.838123Z","pmid":"38696270","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}