{"doi":"10.1164/rccm.202402-0349ed","title":"A New Era in Critical Care Trials: Linking ICU Practice to Long-Term Outcomes","abstract":"complicated mosaic of diseases with protean manifestations in diverse patients.Our current tools to differentiate these conditions are crude, particularly in real time at the bedside.This study and others suggest that there is ample room, and clinical necessity, to add more nuance to how we risk-stratify and manage patients with suspected sepsis.Patients with septic shock should continue to be prioritized for immediate treatment.Additional populations such as those with metastatic cancer or at least three organ failures may also benefit from earlier antibiotic treatment.Most importantly, the study of Hechtman and colleagues puts the onus on us to further refine our understanding of which combinations of host, comorbidity, clinical presentations, illness severity, and pathogen are most likely to benefit from early broad-spectrum antibiotic treatment and which combinations may presage increased risk of harm from immediate antibiotic treatment; and to develop the tools clinicians need to better differentiate between these phenotypes in real time at the bedside.","journal":"American Journal of Respiratory and Critical Care Medicine","year":2024,"id":473068,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":604590,"name":"Neil R. Aggarwal","orcid":"0000-0002-0922-8824","position":1,"is_corresponding":false},{"id":302432,"name":"Mark E. Mikkelsen","orcid":"0000-0002-0349-3782","position":2,"is_corresponding":false},{"id":244864,"name":"Joseph A. Hippensteel","orcid":"0000-0003-4082-6993","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T02:06:01.000126Z","pmid":"38387023","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}