{"doi":"10.1164/rccm.200209-1112oc","title":"Prognostic Implications of Physiologic and Radiographic Changes in Idiopathic Interstitial Pneumonia","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Idiopathic interstitial pneumonias are a diverse group of lung diseases with varied prognoses. We hypothesized that changes in physiologic and radiographic parameters would predict survival. We retrospectively examined 80 patients with usual interstitial pneumonia and 29 patients with nonspecific interstitial pneumonia. Baseline characteristics were examined together with 6-month change in forced vital capacity, diffusing capacity for carbon monoxide, and ground glass infiltrate and fibrosis on high resolution computed tomography. Patients with usual interstitial pneumonia were more likely to have a statistically significant or marginally significant decline in lung volume, diffusing capacity for carbon monoxide, and an increase in ground glass infiltrates (p ⩽ 0.08) compared with patients with nonspecific interstitial pneumonia. For patients with usual interstitial pneumonia, change in forced vital capacity was the best physiologic predictor of mortality (p = 0.05). In a multivariate Cox proportional hazards model controlling for histopathologic diagnosis, gender, smoking history, baseline forced vital capacity, and 6-month change in forced vital capacity, a decrease in forced vital capacity remained an independent risk factor for mortality (decrease &amp;gt; 10%; hazard ratio 2.47; 95% confidence interval 1.29, 4.73; p = 0.006). We conclude that a 6-month change in forced vital capacity gives additional prognostic information to baseline features for patients with idiopathic interstitial pneumonia.</jats:p>","journal":"American Journal of Respiratory and Critical Care Medicine","year":2003,"id":20512,"datarank":21.010847192994543,"base_score":6.2422232654551655,"endowment":6.2422232654551655,"self_citation_contribution":0.9363334898182749,"citation_network_contribution":20.07451370317627,"self_endowment_contribution":0.9363334898182749,"citer_contribution":20.07451370317627,"corpus_percentile":null,"corpus_rank":null,"citation_count":513,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":106572,"name":"Jeanette A. Mumford","orcid":"0000-0002-0926-3531","position":1,"is_corresponding":false},{"id":128800,"name":"Susan Murray","orcid":null,"position":2,"is_corresponding":false},{"id":135303,"name":"Ella A. Kazerooni","orcid":null,"position":3,"is_corresponding":false},{"id":135304,"name":"Barry H. Gross","orcid":null,"position":4,"is_corresponding":false},{"id":33098,"name":"Thomas V. Colby","orcid":"0009-0006-5662-0120","position":5,"is_corresponding":false},{"id":15536,"name":"William D. Travis","orcid":"0000-0003-3160-6729","position":6,"is_corresponding":false},{"id":135305,"name":"Andrew Flint","orcid":null,"position":7,"is_corresponding":false},{"id":135306,"name":"Galen B. Toews","orcid":null,"position":8,"is_corresponding":false},{"id":135307,"name":"Joseph P. Lynch","orcid":null,"position":9,"is_corresponding":false},{"id":33095,"name":"Fernando J. Martinez","orcid":null,"position":10,"is_corresponding":false},{"id":33100,"name":"Kevin R. Flaherty","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.2422232654551655,"endowment":6.2422232654551655,"datacite_reuse_total":6,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12773329","pmcid":null,"openalex_id":"https://openalex.org/W2139890009","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"P50 HL 46487","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"1K23 HL 68713","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"3M01 RR 00042-33S3","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"1K24 HL 04212","title":null},{"funder_name":"NIA NIH HHS","grant_id":"P60 AG 08808-06","title":null}],"total_grants":5,"fwci":19.185,"citation_percentile":0.99615054,"influential_citations":10,"citation_trend":[{"year":2012,"count":33},{"year":2013,"count":26},{"year":2014,"count":33},{"year":2015,"count":34},{"year":2016,"count":20},{"year":2017,"count":22},{"year":2018,"count":28},{"year":2019,"count":17},{"year":2020,"count":28},{"year":2021,"count":21},{"year":2022,"count":16},{"year":2023,"count":10},{"year":2024,"count":17},{"year":2025,"count":4}],"oa_status":"closed","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"http://deepblue.lib.umich.edu/bitstream/2027.42/91973/1/2003%20AJRCCM%20-%20Prognostic%20Implications%20of%20Physiologic%20and%20Radiographic%20Changes%20in%20Idiopathic%20Interstitial%20Pneumonia.pdf","host_type":"GREEN"},{"url":"https://academic.oup.com/ajrccm/article-pdf/168/5/543/67495492/ajrccm_168_5_543.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1164/rccm.200209-1112oc","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12773329","host_type":"repository"}],"fields_of_study":["Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","Occupational and environmental lung diseases","Inhalation and Respiratory Drug Delivery","Medicine","Adult","Aged","Female","Follow-Up Studies","Humans","Lung Diseases, Interstitial","Male","Middle Aged","Predictive Value of Tests","Prognosis","Respiratory Function Tests","Severity of Illness Index","Survival Rate","Time Factors","Tomography, X-Ray Computed"],"mesh_terms":["Adult","Aged","Female","Follow-Up Studies","Humans","Male","Middle Aged","Predictive Value of Tests","Prognosis","Respiratory Function Tests","Severity of Illness Index","Time Factors","Tomography, X-Ray Computed","Survival Rate","Lung Diseases, Interstitial"],"keywords":["Vital capacity","Medicine","Diffusing capacity","Hazard ratio","Internal medicine","Idiopathic pulmonary fibrosis","Usual interstitial pneumonia","Pneumonia","Proportional hazards model","Lung volumes","Lung","Confidence interval","Gastroenterology","Surgery"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.19959616.v1","title":"Additional file 1 of Standardised 3D-CT lung volumes for patients with idiopathic pulmonary fibrosis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19959616","title":"Additional file 1 of Standardised 3D-CT lung volumes for patients with idiopathic pulmonary fibrosis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19959619.v1","title":"Additional file 2 of Standardised 3D-CT lung volumes for patients with idiopathic pulmonary fibrosis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19959619","title":"Additional file 2 of Standardised 3D-CT lung volumes for patients with idiopathic pulmonary fibrosis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25231189.v1","title":"Additional file 1 of The effectiveness and pharmacoeconomic study of using different corticosteroids in the treatment of hypersensitivity pneumonitis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25231189","title":"Additional file 1 of The effectiveness and pharmacoeconomic study of using different corticosteroids in the treatment of hypersensitivity pneumonitis","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-05T08:16:49.958069Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}