{"doi":"10.1162/imag.a.41","title":"Establishing tau-PET cut-points for cognitive diagnosis with 18F-PI-2620 in a multi-ethnoracial cohort","abstract":"Abstract 18F-PI-2620 is a newer tau-PET tracer with minimal off-target binding in the choroid plexus. Defining tau cut-points to differentiate between cognitively unimpaired and impaired individuals is crucial for both biomarker validation and clinical use, but research using 18F-PI-2620 is limited. In 675 participants (mean age: 64, 64% Female, 186 Hispanic, 209 non-Hispanic Black, and 280 non-Hispanic White) from the Health and Aging Brain Study-Health Disparities, we used the area under the receiver operating characteristic curve to identify a region of interest and corresponding cut-point at which 18F-PI-2620 standardized uptake value ratio best distinguished between amyloid negative cognitively unimpaired and amyloid-positive cognitively-impaired individuals. The regional or composite standardized uptake value ratio that maximized sensitivity and specificity (measured by the Youden index) was selected as the best-performing region of interest and was further evaluated using Gaussian mixture modeling. We evaluated the performance of the chosen region of interest and cut-point in the three ethnoracial groups. The best-performing region of interest was the medial temporal composite, with a cut-point of 1.26. This region performed well in Hispanic and non-Hispanic White subgroups, but not in the non-Hispanic Black subgroup. The data show the utility of this region to identify clinically relevant levels of tau. Future work should explore the relationship of tau to comorbid conditions across ethnic and racial groups.","journal":"Imaging Neuroscience","year":2025,"id":523479,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":845364,"name":"Koral V Wheeler","orcid":null,"position":1,"is_corresponding":false},{"id":1388427,"name":"Noelle Lee","orcid":null,"position":2,"is_corresponding":false},{"id":1396380,"name":"Jamie Terner","orcid":null,"position":3,"is_corresponding":false},{"id":1395909,"name":"Maxwell W Hand","orcid":"0009-0003-1732-3324","position":4,"is_corresponding":false},{"id":1395910,"name":"Suchita Ganesan","orcid":"0000-0002-3814-3053","position":5,"is_corresponding":false},{"id":1041804,"name":"Patrick Walsh","orcid":"0000-0002-0130-8766","position":6,"is_corresponding":false},{"id":1396381,"name":"Aisha Greene","orcid":null,"position":7,"is_corresponding":false},{"id":1395911,"name":"Tyler Berkness","orcid":"0000-0002-6002-8967","position":8,"is_corresponding":false},{"id":1395912,"name":"Tiantian Lei","orcid":"0000-0001-9884-185X","position":9,"is_corresponding":false},{"id":226625,"name":"Rema Raman","orcid":"0000-0002-4096-6390","position":10,"is_corresponding":false},{"id":230262,"name":"Robert A. Rissman","orcid":"0000-0001-9245-8278","position":11,"is_corresponding":false},{"id":270461,"name":"Bradley T. Christian","orcid":"0000-0002-9653-559X","position":12,"is_corresponding":false},{"id":632832,"name":"Melissa Petersen","orcid":"0000-0002-3920-5877","position":13,"is_corresponding":false},{"id":329924,"name":"Ann D. Cohen","orcid":"0000-0001-7395-9624","position":14,"is_corresponding":false},{"id":226074,"name":"Beau M. Ances","orcid":"0000-0003-3862-7397","position":15,"is_corresponding":false},{"id":310965,"name":"Karin L. Meeker","orcid":"0000-0002-2677-5715","position":16,"is_corresponding":false},{"id":374491,"name":"Zhengyang Zhou","orcid":"0000-0002-8039-418X","position":17,"is_corresponding":false},{"id":504722,"name":"Rajesh Nandy","orcid":"0000-0003-0209-8059","position":18,"is_corresponding":false},{"id":55010,"name":"Kristine Yaffe","orcid":"0000-0003-0919-3825","position":19,"is_corresponding":false},{"id":270462,"name":"Sid E. 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