{"doi":"10.1161/strokeaha.124.048439","title":"Association of Lp(a) With Stroke and Cerebral Injury on MRI: Insights From the HCHS/SOL (Hispanic Community Health Study/Study of Latinos) and Investigation of Neurocognitive Aging MRI (SOL-INCA MRI)","abstract":"BACKGROUND: Lp(a) (lipoprotein[a]) is a risk factor for cardiovascular disease; however, its association with cerebrovascular disease is not as well established. METHODS: Data from a population-based cohort of Hispanics/Latinos included 16 333 individuals with baseline Lp(a) levels (nmol/L) and self-reported prevalent stroke or transient ischemic attack (TIA). A subset of 2642 individuals with brain magnetic resonance imaging was also included. Linear and multivariate logistic regression assessed the association of Lp(a) with (1) self-reported stroke or TIA, (2) cerebral injury defined as self-reported stroke or TIA or evidence of a stroke on brain magnetic resonance imaging, (3) white matter hyperintensity volume, and (4) silent brain infarcts. Sampling weights were utilized given the HCHS/SOL (Hispanic Community Health Study/Study of Latinos) complex sample design. RESULTS: Mean age±SE was 41.1±0.3 years, 52.0% women, and median interquartile range (Q 1 , Q 3 ) Lp(a) level of 19.7 (7.3–60.6) nmol/L; brain magnetic resonance imaging subset mean age±SE was 49.9±0.4 years, 56.4% women, and median (interquartile range) Lp(a) level of 21.7 (8.1–62.9) nmol/L. Each unit increase in log-transformed Lp(a) was associated with higher odds of self-reported stroke or TIA (odds ratio, 1.13 [95% CI, 1.01–1.27]; P =0.03). Lp(a) levels in the highest quintile (>77 nmol/L) were significantly associated with higher odds of prevalent stroke or TIA compared with Lp(a) <6 nmol/L (first quintile: odds ratio, 1.74 [95% CI, 1.09–2.77]; P =0.02). The highest proportion of cerebral injury was noted in Q5, while the lowest proportion was noted in Q2. When comparing Lp(a) >77 nmol/L with Lp(a) of 6 to <13 nmol/L (second quintile), a significant association was found between Lp(a) and cerebral injury that persisted after fully adjusted models (odds ratio, 2.03 [95% CI, 1.05–3.93]; P =0.03). Each unit increase in log-Lp(a) was associated with a 0.10 increase in log-white matter hyperintensity (β, 0.10; P =0.005). No significant association was found between Lp(a) and silent brain infarcts. CONCLUSIONS: Lp(a) is independently and significantly associated with prevalent stroke/TIA, and white matter hyperintensity, in a large diverse population of Hispanics/Latinos.","journal":"Stroke","year":2025,"id":543575,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":22.178386323199504,"corpus_rank":9377,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8423,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1433160,"name":"Priscilla Duran Luciano","orcid":"0000-0003-4920-2941","position":1,"is_corresponding":false},{"id":327610,"name":"Katrina Swett","orcid":null,"position":2,"is_corresponding":false},{"id":21964,"name":"Robert C. Kaplan","orcid":"0000-0003-1571-4615","position":3,"is_corresponding":false},{"id":336206,"name":"Gregory A. Talavera","orcid":"0000-0001-5360-1107","position":4,"is_corresponding":false},{"id":282469,"name":"Melissa Lamar","orcid":"0000-0001-6130-5543","position":5,"is_corresponding":false},{"id":303806,"name":"Wassim Tarraf","orcid":"0000-0001-8888-7918","position":6,"is_corresponding":false},{"id":474540,"name":"Freddie Márquez","orcid":"0000-0001-9916-9225","position":7,"is_corresponding":false},{"id":293937,"name":"Parag H. Joshi","orcid":"0000-0001-7863-2794","position":8,"is_corresponding":false},{"id":421766,"name":"Linda C. Gallo","orcid":"0000-0002-3678-5888","position":9,"is_corresponding":false},{"id":427001,"name":"Daniela Sotres‐Alvarez","orcid":"0000-0002-3226-6140","position":10,"is_corresponding":false},{"id":311731,"name":"Morgan Gianola","orcid":"0000-0002-6205-3015","position":11,"is_corresponding":false},{"id":37779,"name":"Martha L. Daviglus","orcid":"0000-0002-6791-8727","position":12,"is_corresponding":false},{"id":776214,"name":"Daniel Labovitz","orcid":"0000-0003-0754-4345","position":13,"is_corresponding":false},{"id":303812,"name":"Hector M. González","orcid":"0000-0003-4867-7902","position":14,"is_corresponding":false},{"id":277082,"name":"Charles DeCarli","orcid":"0000-0003-1914-2693","position":15,"is_corresponding":false},{"id":74999,"name":"Carlos J. Rodríguez","orcid":"0000-0003-0860-9008","position":16,"is_corresponding":false},{"id":1433159,"name":"A. Chandra","orcid":"0000-0002-5460-0568","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T02:53:04.088079Z","pmid":"40166810","pmcid":"PMC12101938","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}