{"doi":"10.1161/strokeaha.121.037066","title":"Simultaneous Hemodynamic and Structural Imaging of Ischemic Stroke With Magnetic Resonance Fingerprinting Arterial Spin Labeling","abstract":"Background: Perfusion and structural imaging play an important role in ischemic stroke. Magnetic resonance fingerprinting (MRF) arterial spin labeling (ASL) is a novel noninvasive method of ASL perfusion that allows simultaneous estimation of cerebral blood flow (CBF), bolus arrival time (BAT), and tissue T 1 map in a single scan of <4 minutes. Here, we evaluated the utility of MRF-ASL in patients with ischemic stroke in terms of detecting hemodynamic and structural damage and predicting neurological deficits and disability. Methods: A total of 34 patients were scanned on 3T magnetic resonance imaging. MRF-ASL, standard single-delay pseudo-continuous ASL, T 2 -weighted, and diffusion magnetic resonance imaging were performed. Regions of interest of lesion and contralateral normal tissues were manually delineated. CBF (with 2 different compartmental models), BAT, and tissue T 1 parameters were quantified. Cross-sectional linear regression analyses were performed to examine the relationship between MRF-ASL parameters and National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale. Receiver operating characteristic analyses were performed to determine the utility of MRF-ASL in the classification of stroke lesion voxels. Results: MRF-ASL derived parameters revealed a significant difference between stroke lesion and contralateral normal regions of interest, in that lesion regions manifested a lower CBF 1-compartment ( P <0.001), lower CBF 2-compartment ( P <0.001), longer BAT ( P =0.002), and longer T 1 ( P <0.001) compared with normal regions of interest. NIHSS scores at acute stage revealed a strong association with lesion-normal differences in CBF 1-compartment,diff (β=−0.11, P =0.008), CBF 2-compartment,diff (β=−0.16, P =0.003), and T 1,diff (β=0.008, P =0.001). MRF-ASL parameters were also predictive of NIHSS score and modified Rankin Scale scale measured at a later stage, although the degree of the associations was weaker. These associations tended to be even stronger when the MRF-ASL data were acquired at the acute/subacute stage. Compared with standard pseudo-continuous ASL, the multiparametric capability of MRF-ASL yielded higher area under curve values in the receiver operating characteristic analyses of stroke voxel classifications. Conclusions: MRF-ASL may provide a new approach for quantitative hemodynamic and structural imaging in ischemic stroke.","journal":"Stroke","year":2022,"id":257284,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":492366,"name":"Pan Su","orcid":"0000-0002-6728-5878","position":1,"is_corresponding":false},{"id":399189,"name":"Doris Lin","orcid":"0000-0002-6001-2383","position":2,"is_corresponding":false},{"id":410921,"name":"Emily B. Goldberg","orcid":"0000-0002-2865-7667","position":3,"is_corresponding":false},{"id":410922,"name":"Alexandra Walker","orcid":"0000-0002-0522-3719","position":4,"is_corresponding":false},{"id":399869,"name":"Richard Leigh","orcid":"0000-0002-8285-1815","position":5,"is_corresponding":false},{"id":309226,"name":"Argye E. Hillis","orcid":"0000-0002-5192-1171","position":6,"is_corresponding":false},{"id":57482,"name":"Hanzhang Lu","orcid":"0000-0003-3871-1564","position":7,"is_corresponding":false},{"id":163806,"name":"Hongli Fan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T00:25:30.183987Z","pmid":"35291820","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}