{"doi":"10.1161/strokeaha.107.507020","title":"Choline and Creatine Are Not Reliable Denominators for Calculating Metabolite Ratios in Acute Ischemic Stroke","abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose—</jats:italic>\n            </jats:bold>\n            Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change. We investigated their concentration variation over time after stroke.\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods—</jats:italic>\n            </jats:bold>\n            Choline and creatine concentrations were measured by proton MR spectroscopic imaging in 51 patients at 5 times up to 3 months after stroke.\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results—</jats:italic>\n            </jats:bold>\n            Choline and creatine levels changed significantly in the ischemic region. Choline was significantly reduced during the first 2 weeks after stroke onset (\n            <jats:italic>P</jats:italic>\n            =0.034). Creatine was significantly reduced during the whole period of the study (\n            <jats:italic>P</jats:italic>\n            =0.011).\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion—</jats:italic>\n            </jats:bold>\n            Choline and creatine concentrations are not reliable denominators for metabolite ratios in acute stroke because their levels vary significantly in ischemic brain regions.\n          </jats:p>","journal":"Stroke","year":2008,"id":620157,"datarank":0.5742962094733643,"base_score":3.828641396489095,"endowment":3.828641396489095,"self_citation_contribution":0.5742962094733643,"citation_network_contribution":0.0,"self_endowment_contribution":0.5742962094733643,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1217988,"name":"Vera Cvoro","orcid":"0000-0002-3913-5100","position":1,"is_corresponding":false},{"id":1600796,"name":"Paul A. Armitage","orcid":null,"position":2,"is_corresponding":false},{"id":492202,"name":"Ian Marshall","orcid":"0000-0003-4445-1551","position":3,"is_corresponding":false},{"id":245386,"name":"Mark E. Bastin","orcid":"0000-0002-0490-0845","position":4,"is_corresponding":false},{"id":17637,"name":"Joanna M. Wardlaw","orcid":"0000-0002-9812-6642","position":5,"is_corresponding":false},{"id":1600795,"name":"Susana Muñoz Maniega","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Choline and Creatine Are Not Reliable Denominators for Calculating Metabolite Ratios in Acute Ischemic Stroke","abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose—</jats:italic>\n            </jats:bold>\n            Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change. We investigated their concentration variation over time after stroke.\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods—</jats:italic>\n            </jats:bold>\n            Choline and creatine concentrations were measured by proton MR spectroscopic imaging in 51 patients at 5 times up to 3 months after stroke.\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results—</jats:italic>\n            </jats:bold>\n            Choline and creatine levels changed significantly in the ischemic region. Choline was significantly reduced during the first 2 weeks after stroke onset (\n            <jats:italic>P</jats:italic>\n            =0.034). Creatine was significantly reduced during the whole period of the study (\n            <jats:italic>P</jats:italic>\n            =0.011).\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion—</jats:italic>\n            </jats:bold>\n            Choline and creatine concentrations are not reliable denominators for metabolite ratios in acute stroke because their levels vary significantly in ischemic brain regions.\n          </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18617668","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"G0700704B","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.107.507020","host_type":"publisher"},{"url":"https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.107.507020","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Brain","Humans","Brain Ischemia","Acute Disease","Choline","Creatine","Magnetic Resonance Spectroscopy","Reproducibility of Results","Down-Regulation","Aged","Aged, 80 and over","Middle Aged","Stroke","Biomarkers"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T10:11:31.791784Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}