{"doi":"10.1161/jaha.124.038608","title":"Lipoprotein(a) and Heart Failure Among Black and White Participants in Atherosclerosis Risk in Communities Study, Framingham Offspring Study, and Multi‐Ethnic Study of Atherosclerosis: The Pooling Project","abstract":"BACKGROUND: This study investigated Lp(a) (lipoprotein(a)) levels with heart failure (HF) incidence overall and ejection fraction (EF) subtypes among Black and White participants in a pooled analysis of MESA (Multi-Ethnic Study of Atherosclerosis), FOS (Framingham Offspring Study), and ARIC (Atherosclerosis Risk in Communities Study). METHODS: This study was conducted among 16 771 White and Black participants in ARIC (N=10 347), MESA (N=4150), and FOS (N=2274). Baseline was time of Lp(a) measurement (ARIC Visit 4: 1996-1998; MESA Visit 1: 2000-2002; FOS Cycle 6: 1995-1998). HF with reduced EF (HFrEF) was defined as EF <50% and ≥50% as HF with preserved EF (HFpEF). Cox proportional hazards regression was used to evaluate associations between Lp(a) (log-transformed continuous, dichotomized at ≥30 mg/dL and ≥50 mg/dL, and quartiles) and HF (overall, HFpEF, HFrEF) in the overall population and stratified by race. Analyses were replicated excluding prior history of myocardial infarction. RESULTS: There were 2759 HF cases (HFpEF N=859; HFrEF N=649; EF unknown N=1251) through 2019. Among White participants, Lp(a) ≥50 mg/dL was associated with HF risk overall (hazard ratio [HR], 1.19 [95% CI, 1.07-1.34]) and by EF subtype (HFpEF HR, 1.32 [95% CI, 1.08-1.59]; HFrEF HR, 1.33 [95% CI, 1.05-1.67]). Among Black participants, Lp(a) ≥50 mg/dL was not associated with HF risk overall (HR, 0.93 [95% CI, 0.78-1.11]) or by EF subtype (HFpEF HR, 0.97 [95% CI, 0.69-1.35]; HFrEF HR, 0.89 [95% CI, 0.63-1.26]). Associations were no longer significant after excluding prior myocardial infarction. CONCLUSIONS: Elevated Lp(a) levels are associated with HF risk among White, but not Black individuals, and associations appears to be mostly mediated by a history of myocardial infarction.","journal":"Journal of the American Heart Association","year":2025,"id":521270,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.916,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334853,"name":"Weihua Guan","orcid":"0000-0002-0956-9821","position":1,"is_corresponding":false},{"id":806375,"name":"Yixin Zhang","orcid":"0009-0008-2528-4624","position":2,"is_corresponding":false},{"id":63402,"name":"GEOFFREY H. TISON","orcid":"0000-0002-0310-3326","position":3,"is_corresponding":false},{"id":1041791,"name":"Hiroaki Ikezaki","orcid":"0000-0002-6677-6341","position":4,"is_corresponding":false},{"id":1041792,"name":"Margaret R. Diffenderfer","orcid":"0000-0002-3803-2812","position":5,"is_corresponding":false},{"id":22056,"name":"Ching‐Ti Liu","orcid":"0000-0002-0703-0742","position":6,"is_corresponding":false},{"id":233724,"name":"Ron C. Hoogeveen","orcid":"0000-0003-2399-4653","position":7,"is_corresponding":false},{"id":233725,"name":"Christie M. Ballantyne","orcid":"0000-0002-6432-1730","position":8,"is_corresponding":false},{"id":1041790,"name":"Ernst J. Schaefer","orcid":"0000-0002-7158-3085","position":9,"is_corresponding":false},{"id":235847,"name":"Michael Y. Tsai","orcid":"0000-0001-7553-3408","position":10,"is_corresponding":false},{"id":616257,"name":"Sarah Nomura","orcid":"0000-0001-5472-8302","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:49:44.558743Z","pmid":"40417812","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}