{"doi":"10.1161/jaha.124.034390","title":"Older Adults With Smaller and Less Complex Social Networks Show Deficits in Medial Temporal Cerebrovascular Reactivity","abstract":"ocial isolation is associated with increased risk for stroke and cognitive decline. 1 Although existing research has proposed neuroimmune system dysregulation as a possible underlying mechanism, 1 few studies have investigated cerebrovascular mechanisms in connection to social isolation.Cerebrovascular reactivity (CVR) denotes the ability of cerebral blood vessels to regulate cerebral blood flow (CBF) through dilation or constriction in response to stimuli. 2 The present study examined CVR in response to hypercapnia in select brain regions implicated in social cognition, specifically the hippocampus, parahippocampal gyrus, amygdala, entorhinal cortex, superior frontal gyrus, medial orbitofrontal cortex, anterior cingulate cortex, inferior parietal cortex, and precuneus.We hypothesized that lower social network size and complexity would be associated with reduced CVR in these regions.The data supporting the findings of this study are available from the corresponding author upon reasonable request.Independently living older adults were recruited from the community.Exclusion criteria included history of stroke, dementia, major depression, and other illnesses or medications affecting the central nervous system.","journal":"Journal of the American Heart Association","year":2024,"id":473664,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":283895,"name":"Arunima Kapoor","orcid":"0000-0003-4622-8951","position":1,"is_corresponding":false},{"id":1165332,"name":"Trevor Lohman","orcid":"0000-0002-9634-702X","position":2,"is_corresponding":false},{"id":572971,"name":"Shubir Dutt","orcid":"0000-0002-8408-2220","position":3,"is_corresponding":false},{"id":894364,"name":"John Paul M Alitin","orcid":"0009-0001-5494-9639","position":4,"is_corresponding":false},{"id":572970,"name":"Isabel J. Sible","orcid":"0000-0003-3922-0628","position":5,"is_corresponding":false},{"id":473251,"name":"Jean K. Ho","orcid":"0000-0002-3967-5510","position":6,"is_corresponding":false},{"id":666034,"name":"Aimée Gaubert","orcid":"0000-0001-6812-522X","position":7,"is_corresponding":false},{"id":474218,"name":"Anna E. Blanken","orcid":null,"position":8,"is_corresponding":false},{"id":298756,"name":"Mara Mather","orcid":"0000-0003-4331-6112","position":9,"is_corresponding":false},{"id":290778,"name":"Xingfeng Shao","orcid":"0000-0002-4130-6204","position":10,"is_corresponding":false},{"id":244996,"name":"Danny J.J. Wang","orcid":"0000-0002-0840-7062","position":11,"is_corresponding":false},{"id":283896,"name":"Daniel A. Nation","orcid":"0000-0002-9123-0658","position":12,"is_corresponding":false},{"id":1004408,"name":"Evelyn Chang","orcid":"0009-0007-3279-959X","position":0,"is_corresponding":true}],"reference_count":5,"raw_metadata":null,"created_at":"2026-07-19T02:06:04.967429Z","pmid":"39011958","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}