{"doi":"10.1161/jaha.123.031742","title":"Representation of Real‐World Adults With Chronic Kidney Disease in Clinical Trials Supporting Blood Pressure Treatment Targets","abstract":"BACKGROUND: Little is known about how well trial participants with chronic kidney disease (CKD) represent real-world adults with CKD. We assessed the population representativeness of clinical trials supporting the 2021 Kidney Disease: Improving Global Outcomes blood pressure (BP) guidelines in real-world adults with CKD. METHODS AND RESULTS: Using a cross-sectional analysis, we identified patients with CKD who met the guideline definition of hypertension based on use of antihypertensive medications or sustained systolic BP ≥120 mm Hg in 2019 in the Veterans Affairs and Kaiser Permanente of Southern California. We applied the eligibility criteria from 3 BP target trials, SPRINT (Systolic Pressure Intervention Trial), ACCORD (Action to Control Cardiovascular Risk in Diabetes), and AASK (African American Study of Kidney Disease), to estimate the proportion of adults with a systolic BP above the guideline-recommended target and the proportion who met eligibility criteria for ≥1 trial. We identified 503 480 adults in the Veterans Affairs and 73 412 adults in Kaiser Permanente of Southern California with CKD and hypertension in 2019. We estimated 79.7% in the Veterans Affairs and 87.3% in the Kaiser Permanente of Southern California populations had a systolic BP ≥120 mm Hg; only 23.8% [23.7%-24.0%] in the Veterans Affairs and 20.8% [20.5%-21.1%] in Kaiser Permanente of Southern California were trial-eligible. Among trial-ineligible patients, >50% met >1 exclusion criteria. CONCLUSIONS: Major BP target trials were representative of fewer than 1 in 4 real-world adults with CKD and hypertension. A large proportion of adults who are at risk for cardiovascular morbidity from hypertension and susceptible to adverse treatment effects lack relevant treatment information.","journal":"Journal of the American Heart Association","year":2024,"id":459345,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6719,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":968361,"name":"Jaejin An","orcid":"0000-0002-3161-5732","position":1,"is_corresponding":false},{"id":1286093,"name":"Mengjiao Huang","orcid":"0000-0002-8245-6508","position":2,"is_corresponding":false},{"id":1035931,"name":"Mengnan Zhou","orcid":"0009-0004-9657-0135","position":3,"is_corresponding":false},{"id":234902,"name":"Maria E. Montez‐Rath","orcid":"0000-0001-5154-2182","position":4,"is_corresponding":false},{"id":371486,"name":"Fang Niu","orcid":"0009-0004-3439-7410","position":5,"is_corresponding":false},{"id":436521,"name":"John J. Sim","orcid":"0000-0001-9456-8243","position":6,"is_corresponding":false},{"id":782534,"name":"Alan C. Pao","orcid":"0000-0001-8589-9083","position":7,"is_corresponding":false},{"id":74080,"name":"Vivek Charu","orcid":"0000-0002-7147-9026","position":8,"is_corresponding":false},{"id":305264,"name":"Michelle C. Odden","orcid":"0000-0002-5974-3648","position":9,"is_corresponding":false},{"id":295976,"name":"Manjula Kurella Tamura","orcid":"0000-0001-5227-2479","position":10,"is_corresponding":false},{"id":723184,"name":"June Li","orcid":"0009-0007-6242-5839","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:03:55.280882Z","pmid":"38533947","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}