{"doi":"10.1161/jaha.122.027725","title":"Clinical Metabolomic Landscape of Cardiovascular Physiology and Disease","abstract":"etabolites are small molecules that act as intermediates, end products, or signaling molecules of cellular and systemic metabolism.Metabolomics is an emerging field in cardiovascular medicine broadly defined as the systematic measurement and study of metabolites in a biological specimen, such as serum or tissues.Cardiovascular disease (CVD) is often the downstream manifestation of metabolic dysregulation at the systemic or cellular levels, and thus there is great interest in understanding the metabolites associated with present and future CVD outcomes. 1,2Metabolomics also aids in the mechanistic understanding of CVD and patient-level response to specific treatments. 1,2In this Perspective, we discuss the technologies used in metabolomic studies, statistical considerations, examples of metabolomics in cardiovascular research, and future capabilities.","journal":"Journal of the American Heart Association","year":2023,"id":393030,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9451,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":328234,"name":"John T. Wilkins","orcid":"0000-0002-8781-1329","position":1,"is_corresponding":false},{"id":585920,"name":"Konrad Teodor Sawicki","orcid":"0000-0003-2124-0081","position":2,"is_corresponding":false},{"id":1166955,"name":"Keenan S. Fine","orcid":"0000-0001-8449-0198","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T01:19:01.355412Z","pmid":"36892040","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}