{"doi":"10.1161/jaha.121.020809","title":"Peripheral Blood Cytopenia and Risk of Cardiovascular Disease and Mortality","abstract":"Background Individual blood cell count abnormalities have been associated with cardiovascular disease and increased mortality. In this study, we defined a “cytopenia phenotype,” reflecting bone marrow hypoproliferation, to determine if peripheral blood cytopenia is associated with increased cardiovascular disease and mortality risk. Methods and Results Study participants were derived from a biracial observational cohort study, REGARDS (Reasons for Geographic and Racial Differences in Stroke), that enrolled 30 239 Black and White participants aged ≥45 years between 2003 and 2007. Median follow up was ≈9 years. The current study included 19 864 participants from REGARDS study (37.9% men, 40% Black participants) who have complete blood count available at study enrollment. We defined a cytopenia phenotype based on age‐, sex‐, and race‐adjusted lowest fifth percentile of blood counts. Multivariable Cox proportional hazards models estimated the hazard ratios (HR) and 95% CI of cytopenia for mortality and incident cardiovascular disease in adjusted models. Mean age of the study participants was 64 years (SD:9.7). The prevalence of cytopenia was 1.9% (n=378). Cytopenia was associated with increased risk of all‐cause mortality (HR, 1.73; 95% CI, 1.34–2.22) and cardiovascular disease mortality (HR, 1.56; 95% CI, 1.11–2.29). Cytopenia was associated with stroke risk in Black but not White participants (HR, 1.96 versus 0.86; P ‐interaction for race=0.08) and was not associated with coronary heart disease risk. Conclusions We defined a cytopenia phenotype with clinical implications for mortality and stroke risk in a large biracial and geographically diverse population. Whether generated through somatic mutations or decreased organ function, cytopenia was associated with mortality risk and was a race‐specific risk factor for stroke.","journal":"Journal of the American Heart Association","year":2021,"id":204537,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9496,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":725393,"name":"Insu Koh","orcid":"0000-0001-9425-077X","position":1,"is_corresponding":false},{"id":24975,"name":"Marguerite R. Irvin","orcid":"0000-0002-1442-2023","position":2,"is_corresponding":false},{"id":24984,"name":"Leslie A. Lange","orcid":"0000-0002-4220-6766","position":3,"is_corresponding":false},{"id":668191,"name":"Damon E. Houghton","orcid":"0000-0002-6065-9523","position":4,"is_corresponding":false},{"id":786884,"name":"Diego Adrianzen Herrera","orcid":"0000-0003-0168-2165","position":5,"is_corresponding":false},{"id":228354,"name":"Monika M. Safford","orcid":"0000-0002-3060-0563","position":6,"is_corresponding":false},{"id":51219,"name":"Mary Cushman","orcid":"0000-0002-7871-6143","position":7,"is_corresponding":false},{"id":262392,"name":"Smita Bhatia","orcid":"0000-0002-7755-5683","position":8,"is_corresponding":false},{"id":374898,"name":"Neil A. Zakai","orcid":"0000-0001-8824-4410","position":9,"is_corresponding":false},{"id":301174,"name":"Radhika Gangaraju","orcid":"0000-0002-5542-4754","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-18T23:51:26.121843Z","pmid":"34514816","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}