{"doi":"10.1161/jaha.120.019135","title":"Associations of Serum Nonesterified Fatty Acids With Coronary Heart Disease Mortality and Nonfatal Myocardial Infarction: The CHS (Cardiovascular Health Study) Cohort","abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background</jats:title>\n            <jats:p xml:lang=\"en\">\n              Significant associations have been reported between serum total nonesterified fatty acid (NEFA) concentrations and coronary heart disease (CHD) mortality and incident nonfatal myocardial infarction (MI) in some prospective cohort studies. Little is known about whether individual or subclasses (saturated, polyunsaturated [n‐6 and n‐3], and\n              <jats:italic>trans</jats:italic>\n              fatty acids) of serum NEFAs relate to CHD mortality and nonfatal MI.\n            </jats:p>\n          </jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results</jats:title>\n            <jats:p xml:lang=\"en\">\n              CHS (Cardiovascular Health Study) participants (N=1681) who had no history of MI, angina, or revascularization or were free of MI at baseline (1996–1997) were included. NEFAs were quantified using gas chromatography. Cox regression analysis was used to evaluate associations of 5 subclasses and individual NEFAs with CHD composite (CHD mortality and nonfatal MI), CHD mortality, and incident nonfatal MI. During a median follow‐up of 11.7 years, 266 cases of CHD death and 271 cases of nonfatal MI occurred. In the fully adjusted model, no significant associations were identified between individual NEFA and CHD composite. Exploratory analyses indicated that lauric acid (12:0) was negatively associated (hazard ratio [HR], 0.76; 95% CI, 0.59–0.98;\n              <jats:italic>P</jats:italic>\n              =0.0328) and dihomo‐γ‐linolenic acid (20:3n‐6) was positively associated with CHD mortality (HR, 1.34; 95% CI, 1.02–1.76;\n              <jats:italic>P</jats:italic>\n              =0.0351). Elaidic acid (18:1n‐7\n              <jats:italic>t</jats:italic>\n              ) was positively associated with incident nonfatal MI (HR, 1.46; 95% CI, 1.01–2.12;\n              <jats:italic>P</jats:italic>\n              =0.0445). No significant associations were observed for NEFA subclass and any outcomes.\n            </jats:p>\n          </jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions</jats:title>\n            <jats:p xml:lang=\"en\">In CHS participants, 2 NEFAs, dihomo‐γ‐linolenic and elaidic acids, were positively associated with CHD mortality and nonfatal MI, respectively, suggesting potential susceptibility biomarkers for risks of CHD mortality and nonfatal MI.</jats:p>\n          </jats:sec>","journal":"Journal of the American Heart Association","year":2021,"id":653538,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":449335,"name":"Petra Bůžková","orcid":"0000-0001-8299-4974","position":1,"is_corresponding":false},{"id":274356,"name":"Nirupa R. Matthan","orcid":"0000-0002-7037-9779","position":2,"is_corresponding":false},{"id":98937,"name":"Luc Djoussé","orcid":"0000-0002-9902-3047","position":3,"is_corresponding":false},{"id":57361,"name":"Calvin H. Hirsch","orcid":"0000-0001-6516-9307","position":4,"is_corresponding":false},{"id":246786,"name":"Jorge R. Kizer","orcid":"0000-0001-9936-7803","position":5,"is_corresponding":false},{"id":551024,"name":"W. T. Longstreth","orcid":null,"position":6,"is_corresponding":false},{"id":291349,"name":"Kenneth J. Mukamal","orcid":"0000-0001-8450-6970","position":7,"is_corresponding":false},{"id":73082,"name":"Alice H. Lichtenstein","orcid":"0000-0002-1053-9478","position":8,"is_corresponding":false},{"id":397701,"name":"Neil K. Huang","orcid":"0000-0002-2849-7018","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Associations of Serum Nonesterified Fatty Acids With Coronary Heart Disease Mortality and Nonfatal Myocardial Infarction: The CHS (Cardiovascular Health Study) Cohort","abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background</jats:title>\n            <jats:p xml:lang=\"en\">\n              Significant associations have been reported between serum total nonesterified fatty acid (NEFA) concentrations and coronary heart disease (CHD) mortality and incident nonfatal myocardial infarction (MI) in some prospective cohort studies. Little is known about whether individual or subclasses (saturated, polyunsaturated [n‐6 and n‐3], and\n              <jats:italic>trans</jats:italic>\n              fatty acids) of serum NEFAs relate to CHD mortality and nonfatal MI.\n            </jats:p>\n          </jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results</jats:title>\n            <jats:p xml:lang=\"en\">\n              CHS (Cardiovascular Health Study) participants (N=1681) who had no history of MI, angina, or revascularization or were free of MI at baseline (1996–1997) were included. NEFAs were quantified using gas chromatography. Cox regression analysis was used to evaluate associations of 5 subclasses and individual NEFAs with CHD composite (CHD mortality and nonfatal MI), CHD mortality, and incident nonfatal MI. During a median follow‐up of 11.7 years, 266 cases of CHD death and 271 cases of nonfatal MI occurred. In the fully adjusted model, no significant associations were identified between individual NEFA and CHD composite. Exploratory analyses indicated that lauric acid (12:0) was negatively associated (hazard ratio [HR], 0.76; 95% CI, 0.59–0.98;\n              <jats:italic>P</jats:italic>\n              =0.0328) and dihomo‐γ‐linolenic acid (20:3n‐6) was positively associated with CHD mortality (HR, 1.34; 95% CI, 1.02–1.76;\n              <jats:italic>P</jats:italic>\n              =0.0351). Elaidic acid (18:1n‐7\n              <jats:italic>t</jats:italic>\n              ) was positively associated with incident nonfatal MI (HR, 1.46; 95% CI, 1.01–2.12;\n              <jats:italic>P</jats:italic>\n              =0.0445). No significant associations were observed for NEFA subclass and any outcomes.\n            </jats:p>\n          </jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions</jats:title>\n            <jats:p xml:lang=\"en\">In CHS participants, 2 NEFAs, dihomo‐γ‐linolenic and elaidic acids, were positively associated with CHD mortality and nonfatal MI, respectively, suggesting potential susceptibility biomarkers for risks of CHD mortality and nonfatal MI.</jats:p>\n          </jats:sec>","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33682438","pmcid":"PMC8174223","openalex_id":"https://openalex.org/W3135036996","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC085081","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 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HHS","grant_id":"HHSN268201800001C","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01 HC085079","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"N01HC85081","title":null},{"funder_name":"National Institutes of Health","grant_id":"N01HC085083-021","title":"CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84"},{"funder_name":"National Institutes of Health","grant_id":"N01HC085081-016","title":"CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84"},{"funder_name":"National Institutes of Health","grant_id":"3R01AG053325-02S1","title":"Non-esterified Fatty Acids and Cardiometabolic Disease in Older Adults"},{"funder_name":"National Institutes of Health","grant_id":"N01HC085086-019","title":"CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS"},{"funder_name":"National Institutes of Health","grant_id":"N01HC085079-023","title":"CORONARY HEART DISEASE AND STROKE"},{"funder_name":"National Institutes of Health","grant_id":"1R13AG013039-01","title":"1995 SUMMER INSTITUTE IN GERIATRIC MEDICINE"},{"funder_name":"National Institutes of Health","grant_id":"3U01HL130114-03S1","title":"CHS research resources for the cardiovascular health of older adults"},{"funder_name":"National Institutes of Health","grant_id":"N01HC085082-024","title":"CORONARY HEART DISEASE AND STROKE"},{"funder_name":"National Institutes of Health","grant_id":"1U01HL080295-01","title":"CHS Events Follow-up Study"},{"funder_name":"National Institutes of Health","grant_id":"5R01AG023629-03","title":"Exceptional aging: 12 year trajectories to function"},{"funder_name":"National Institutes of Health","grant_id":"N01HC055222-001","title":"CHS-Transition Phase -268055222"},{"funder_name":"National Institutes of Health","grant_id":"N01HC085080-018","title":"CORONARY HEART DISEASE &STROKE IN THE 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