{"doi":"10.1161/jaha.118.009543","title":"Atrial Fibrillation and Risk of Cancer: A Danish Population‐Based Cohort Study","abstract":"\n Background\n \n Atrial fibrillation (\n AF\n ) and cancer are frequent diseases worldwide. The timewise association between the diagnosis of\n AF\n and a subsequent diagnosis of cancer may clarify whether a mutual cause exists, and may also guide clinicians about time windows of high risk of cancer occurrence.\n \n \n \n Methods and Results\n \n We conducted a population‐based cohort study among 26 222 men and 28 879 women free of\n AF\n and cancer at baseline based on the Danish Diet, Cancer and Health study. The participants were followed for the development of\n AF\n (the Danish National Patient Registry) and subsequent cancer (the Danish Cancer Registry) until 2013. We used Cox proportional hazard models with new‐onset\n AF\n as time‐dependent exposure. The men (median age 56 years) and women (median age 56 years) were followed for medians of 16.7 and 19.6 years, respectively.\n AF\n was associated with higher risks of any type of cancer (men: hazard ratio [\n HR\n ] 1.41, 95% confidence interval [\n CI\n ], 1.26–1.58; women:\n HR\n 1.15, 95%\n CI\n , 1.02–1.32), and for men only, lung (\n HR\n 1.66, 95%\n CI\n , 1.19–2.30), and colorectal cancer (\n HR\n 1.37, 95%\n CI\n , 1.02–1.85). Within the initial 90 days following the diagnosis of\n AF\n , the risks of any type of cancer (men:\n HR\n 2.89, 95%\n CI\n , 2.10–3.98; women:\n HR\n 3.72, 95%\n CI\n , 2.49–5.56), lung (men:\n HR\n 7.70, 95%\n CI\n , 4.34–13.68; women:\n HR\n 7.98, 95%\n CI\n , 3.96–16.09), and colorectal cancer (men:\n HR\n 3.35, 95%\n CI\n , 1.03–10.90; women:\n HR\n 5.91, 95%\n CI\n , 2.44–14.29) were higher for men and women.\n \n \n \n Conclusions\n \n A diagnosis of\n AF\n is associated with a higher incidence rate of cancer among men and women. The cancer incidence rate is particularly elevated within 90 days after the diagnosis of\n AF\n .\n \n ","journal":"Journal of the American Heart Association","year":2018,"id":592886,"datarank":0.6554171778700533,"base_score":4.3694478524670215,"endowment":4.3694478524670215,"self_citation_contribution":0.6554171778700533,"citation_network_contribution":0.0,"self_endowment_contribution":0.6554171778700533,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":78,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1517275,"name":"Amanda M. S. Christesen","orcid":null,"position":1,"is_corresponding":false},{"id":227398,"name":"Morten Fenger‐Grøn","orcid":"0000-0002-6354-5871","position":2,"is_corresponding":false},{"id":39584,"name":"Anne Tjønneland","orcid":"0000-0003-4385-2097","position":3,"is_corresponding":false},{"id":299066,"name":"Lars Frost","orcid":"0000-0001-9215-9796","position":4,"is_corresponding":false},{"id":299064,"name":"Nicklas Vinter","orcid":"0000-0003-0558-8483","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Atrial Fibrillation and Risk of Cancer: A Danish Population‐Based Cohort Study","abstract":"\n Background\n \n Atrial fibrillation (\n AF\n ) and cancer are frequent diseases worldwide. The timewise association between the diagnosis of\n AF\n and a subsequent diagnosis of cancer may clarify whether a mutual cause exists, and may also guide clinicians about time windows of high risk of cancer occurrence.\n \n \n \n Methods and Results\n \n We conducted a population‐based cohort study among 26 222 men and 28 879 women free of\n AF\n and cancer at baseline based on the Danish Diet, Cancer and Health study. The participants were followed for the development of\n AF\n (the Danish National Patient Registry) and subsequent cancer (the Danish Cancer Registry) until 2013. We used Cox proportional hazard models with new‐onset\n AF\n as time‐dependent exposure. The men (median age 56 years) and women (median age 56 years) were followed for medians of 16.7 and 19.6 years, respectively.\n AF\n was associated with higher risks of any type of cancer (men: hazard ratio [\n HR\n ] 1.41, 95% confidence interval [\n CI\n ], 1.26–1.58; women:\n HR\n 1.15, 95%\n CI\n , 1.02–1.32), and for men only, lung (\n HR\n 1.66, 95%\n CI\n , 1.19–2.30), and colorectal cancer (\n HR\n 1.37, 95%\n CI\n , 1.02–1.85). Within the initial 90 days following the diagnosis of\n AF\n , the risks of any type of cancer (men:\n HR\n 2.89, 95%\n CI\n , 2.10–3.98; women:\n HR\n 3.72, 95%\n CI\n , 2.49–5.56), lung (men:\n HR\n 7.70, 95%\n CI\n , 4.34–13.68; women:\n HR\n 7.98, 95%\n CI\n , 3.96–16.09), and colorectal cancer (men:\n HR\n 3.35, 95%\n CI\n , 1.03–10.90; women:\n HR\n 5.91, 95%\n CI\n , 2.44–14.29) were higher for men and women.\n \n \n \n Conclusions\n \n A diagnosis of\n AF\n is associated with a higher incidence rate of cancer among men and women. The cancer incidence rate is particularly elevated within 90 days after the diagnosis of\n AF\n .\n \n ","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30371150","pmcid":"PMC6201425","openalex_id":"https://openalex.org/W30371150","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.00485256,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.1161/jaha.118.009543","host_type":"publisher"},{"url":"https://www.ahajournals.org/doi/full/10.1161/JAHA.118.009543","host_type":"publisher"},{"url":"https://cyberleninka.ru/article/n/sotsialnoe-samoopredelenie-molodezhi.pdf","host_type":"journal"},{"url":"https://curis.ku.dk/ws/files/210437702/Atrial_Fibrillation_and_Risk_of_Cancer.pdf","host_type":"repository"},{"url":"https://doaj.org/article/a5501cb92df344968d70df13f2df0f5d","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6201425","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6201425","host_type":"repository"},{"url":"https://curis.ku.dk/portal/da/publications/atrial-fibrillation-and-risk-of-cancer(5f48b7a9-596f-4589-b196-dfc36a1c5808).html","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6201425","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6201425?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Atrial Fibrillation Management and Outcomes","Cardiovascular Disease and Adiposity","Aged","Atrial Fibrillation","Breast Neoplasms","Cohort Studies","Colorectal Neoplasms","Denmark","Female","Humans","Incidence","Lung Neoplasms","Male","Middle Aged","Neoplasms","Proportional Hazards Models","Prostatic Neoplasms"],"mesh_terms":["Humans","Neoplasms","Breast Neoplasms","Colorectal Neoplasms","Lung Neoplasms","Prostatic Neoplasms","Atrial Fibrillation","Incidence","Proportional Hazards Models","Cohort Studies","Aged","Middle Aged","Denmark","Female","Male"],"keywords":["Geology","Men","Atrial fibrillation","Women","epidemiology","Cancer And Stroke"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Reduced inequalities"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T16:04:06.110170Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}