{"doi":"10.1161/circulationaha.124.072958","title":"Reprogrammed Smooth Muscle Cells for Vascular Repair: A New Path to Healing Ischemic Tissue","abstract":"Ischemic cardiovascular disease remains one of the major causes of death and disability globally due to insufficient blood supply to vital organs and tissues.This vascular insufficiency poses a significant challenge, highlighting the urgent need for effective regenerative therapies capable of promoting neovascularization-the formation of new blood vessels-to restore adequate tissue perfusion and functionality.While existing regenerative therapies have leveraged endothelial cells (ECs) to promote capillary formation 1 , their impact on the growth of larger, stable vessels remains constrained.The formation and maintenance of arterioles, arteries, and stable capillary structures require not only endothelial cells but also mural cells, including pericytes and smooth muscle cells (SMCs), which are vital for vessel stabilization and maturation.Despite the critical role of mural cells in vascular health and repair, few studies have successfully harnessed reprogrammed mural cells for therapeutic applications, leaving a gap in achieving comprehensive vascular regeneration.","journal":"Circulation","year":2025,"id":564219,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":307177,"name":"Qian Li","orcid":"0000-0001-7614-5618","position":0,"is_corresponding":true}],"reference_count":9,"raw_metadata":null,"created_at":"2026-07-19T02:56:20.933088Z","pmid":"40228069","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}