{"doi":"10.1161/circulationaha.124.068669","title":"Associations of “Weekend Warrior” Physical Activity With Incident Disease and Cardiometabolic Health","abstract":"BACKGROUND: Achievement of guideline-recommended levels of physical activity (≥150 minutes of moderate-to-vigorous physical activity per week) is associated with lower risk of adverse cardiovascular events and represents an important public health priority. Although physical activity commonly follows a “weekend warrior” pattern, in which most moderate-to-vigorous physical activity is concentrated in 1 or 2 days rather than spread more evenly across the week (regular), the effects of physical activity pattern across a range of incident diseases, including cardiometabolic conditions, are unknown. METHODS: We tested associations between physical activity pattern and incidence of 678 conditions in 89 573 participants (62±8 years of age; 56% women) of the UK Biobank prospective cohort study who wore an accelerometer for 1 week between June 2013 and December 2015. Models were adjusted for multiple baseline clinical factors, and P value thresholds were corrected for multiplicity. RESULTS: When compared to inactive (<150 minutes moderate-to-vigorous physical activity/week), both weekend warrior (267 total associations; 264 [99%] with lower disease risk; hazard ratio [HR] range, 0.35–0.89) and regular activity (209 associations; 205 [98%] with lower disease risk; HR range, 0.41–0.88) were broadly associated with lower risk of incident disease. The strongest associations were observed for cardiometabolic conditions such as incident hypertension (weekend warrior: HR, 0.77 [95% CI, 0.73–0.80]; P =1.2×10 -27 ; regular: HR, 0.72 [95% CI, 0.68–0.77]; P =4.5×10 -28 ), diabetes (weekend warrior: HR, 0.57 [95% CI, 0.51–0.62]; P =3.9×10 -32 ; regular: HR, 0.54 [95% CI, 0.48–0.60]; P =8.7×10 -26 ), obesity (weekend warrior: HR, 0.55 [95% CI, 0.50–0.60]; P =2.4×10 -43 , regular: HR, 0.44 [95% CI, 0.40–0.50]; P =9.6×10 -47 ), and sleep apnea (weekend warrior: HR, 0.57 [95% CI, 0.48–0.69]; P =1.6×10 -9 ; regular: HR, 0.49 [95% CI, 0.39–0.62]; P =7.4×10 -10 ). When weekend warrior and regular activity were compared directly, there were no conditions for which effects differed significantly. Observations were similar when activity was thresholded at the sample median (≥230.4 minutes of moderate-to-vigorous physical activity/week). CONCLUSIONS: Achievement of measured physical activity volumes consistent with guideline recommendations is associated with lower risk for >200 diseases, with prominent effects on cardiometabolic conditions. Associations appear similar whether physical activity follows a weekend warrior pattern or is spread more evenly throughout the week.","journal":"Circulation","year":2024,"id":417264,"datarank":0.6515708132780527,"base_score":4.343805421853684,"endowment":4.343805421853684,"self_citation_contribution":0.6515708132780527,"citation_network_contribution":0.0,"self_endowment_contribution":0.6515708132780527,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9599,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":639947,"name":"Mostafa A. Al‐Alusi","orcid":"0000-0002-9359-1641","position":1,"is_corresponding":false},{"id":886,"name":"Joel Rämö","orcid":"0000-0002-6429-5149","position":2,"is_corresponding":false},{"id":902,"name":"James P. Pirruccello","orcid":"0000-0001-6088-4037","position":3,"is_corresponding":false},{"id":316988,"name":"Timothy W. Churchill","orcid":"0000-0002-0215-3049","position":4,"is_corresponding":false},{"id":1083,"name":"Steven A. Lubitz","orcid":"0000-0002-9599-4866","position":5,"is_corresponding":false},{"id":464218,"name":"Mahnaz Maddah","orcid":"0000-0002-9837-6000","position":6,"is_corresponding":false},{"id":481021,"name":"J. Sawalla Guseh","orcid":"0000-0003-0992-5635","position":7,"is_corresponding":false},{"id":896,"name":"Patrick T. Ellinor","orcid":"0000-0002-2067-0533","position":8,"is_corresponding":false},{"id":552483,"name":"Shaan Khurshid","orcid":"0000-0002-2840-4539","position":9,"is_corresponding":false},{"id":885,"name":"Shinwan Kany","orcid":"0000-0001-8113-733X","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:56:50.743370Z","pmid":"39324186","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}