{"doi":"10.1161/circulationaha.124.067882","title":"Hemodynamic Forces and Atherosclerosis: HEG1 at the Center of the Jigsaw Puzzle","abstract":"Hemodynamic forces provide the endothelium with a relentless reminder of vitality.At every heart beat, a bolus of blood enters the vascular tree with dynamic and complex physical effects.Amongst those are pulsatile stretch and shear stress, the frictional force exerted on the endothelial surface by the flow of blood.Shear stress is, in turn, affected by the geometry of the vascular tree, whereby curvatures and bifurcations create disturbed shear stress, while straight vascular regions make shear stress linear and laminar.Why does this matter, and why should we care?","journal":"Circulation","year":2024,"id":486924,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9581,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":428134,"name":"M. Luisa Iruela‐Arispe","orcid":"0000-0002-3050-4168","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-19T02:08:06.013846Z","pmid":"38588335","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}