{"doi":"10.1161/circulationaha.121.058162","title":"Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults","abstract":"BACKGROUND: The 2018 physical activity guidelines for Americans recommend a minimum of 150 to 300 min/wk of moderate physical activity (MPA), 75 to 150 min/wk of vigorous physical activity (VPA), or an equivalent combination of both. However, it remains unclear whether higher levels of long-term VPA and MPA are, independently and jointly, associated with lower mortality. METHODS: A total of 116 221 adults from 2 large prospective US cohorts (Nurses' Health Study and Health Professionals Follow-up Study, 1988-2018) were analyzed. Detailed self-reported leisure-time physical activity was assessed with a validated questionnaire, repeated up to 15 times during the follow-up. Cox regression was used to estimate the hazard ratio and 95% CI of the association between long-term leisure-time physical activity intensity and all-cause and cause-specific mortality. RESULTS: During 30 years of follow-up, we identified 47 596 deaths. In analyses mutually adjusted for MPA and VPA, hazard ratios comparing individuals meeting the long-term leisure-time VPA guideline (75-149 min/wk) versus no VPA were 0.81 (95% CI, 0.76-0.87) for all-cause mortality, 0.69 (95% CI, 0.60-0.78) for cardiovascular disease (CVD) mortality, and 0.85 (95% CI, 0.79-0.92) for non-CVD mortality. Meeting the long-term leisure-time MPA guideline (150-299 min/wk) was similarly associated with lower mortality: 19% to 25% lower risk of all-cause, CVD, and non-CVD mortality. Compared with those meeting the long-term leisure-time physical activity guidelines, participants who reported 2 to 4 times above the recommended minimum of long-term leisure-time VPA (150-299 min/wk) or MPA (300-599 min/wk) showed 2% to 4% and 3% to 13% lower mortality, respectively. Higher levels of either long-term leisure-time VPA (≥300 min/wk) or MPA (≥600 min/wk) did not clearly show further lower all-cause, CVD, and non-CVD mortality or harm. In joint analyses, for individuals who reported <300 min/wk of long-term leisure-time MPA, additional leisure-time VPA was associated with lower mortality; however, among those who reported ≥300 min/wk of long-term leisure-time MPA, additional leisure-time VPA did not appear to be associated with lower mortality beyond MPA. CONCLUSIONS: The nearly maximum association with lower mortality was achieved by performing ≈150 to 300 min/wk of long-term leisure-time VPA, 300 to 600 min/wk of long-term leisure-time MPA, or an equivalent combination of both.","journal":"Circulation","year":2022,"id":232022,"datarank":0.8540598208204051,"base_score":5.6937321388027,"endowment":5.6937321388027,"self_citation_contribution":0.8540598208204051,"citation_network_contribution":0.0,"self_endowment_contribution":0.8540598208204051,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":296,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9164,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":78911,"name":"Leandro F. M. Rezende","orcid":"0000-0002-7469-1399","position":1,"is_corresponding":false},{"id":577040,"name":"Hee‐Kyung Joh","orcid":"0000-0003-3854-7012","position":2,"is_corresponding":false},{"id":286846,"name":"NaNa Keum","orcid":null,"position":3,"is_corresponding":false},{"id":648091,"name":"Gérson Ferrari","orcid":"0000-0003-3177-6576","position":4,"is_corresponding":false},{"id":78909,"name":"Juan Pablo Rey-López","orcid":"0000-0002-7201-2006","position":5,"is_corresponding":false},{"id":14733,"name":"Eric B. Rimm","orcid":"0000-0002-1402-7250","position":6,"is_corresponding":false},{"id":230958,"name":"Fred K. Tabung","orcid":"0000-0001-8193-7150","position":7,"is_corresponding":false},{"id":86230,"name":"Edward L. Giovannucci","orcid":"0000-0002-6123-0219","position":8,"is_corresponding":false},{"id":240836,"name":"Dong Hoon Lee","orcid":"0000-0003-1329-4637","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:20:51.245255Z","pmid":"35876019","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}