{"doi":"10.1161/circulationaha.120.053025","title":"DAMPening Mortality in COVID-19","abstract":"ith subsequent waves of the coronavirus disease 2019 (COVID-19) pandemic driving ever-climbing mortality, we are currently using dexamethasone as one of the few beneficial treatments for patients with COVID-19 who require oxygen supplementation, providing proof of principle that a dysregulated inflammatory response underlies poor outcomes in COVID-19. Therefore, optimization of the anti-inflammatory approach is likely to save lives. Although great excitement has surrounded the announcement of the potential effectiveness of several vaccines, not much is known yet about the durability of their efficacy, and several logistical issues surrounding mass vaccination efforts have been raised. Therefore, studies into the pathophysiology of the dysregulated immune response that drives COVID-19, and formal testing of already available anti-inflammatory agents, is still warranted to drive down COVID-19-associated mortality.","journal":"Circulation","year":2021,"id":214298,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":807746,"name":"Bart Spaetgens","orcid":"0000-0003-3062-2612","position":1,"is_corresponding":false},{"id":254368,"name":"Prabhakara R. Nagareddy","orcid":"0000-0002-0294-641X","position":2,"is_corresponding":false},{"id":254370,"name":"Andrew Murphy","orcid":"0000-0001-7039-7777","position":3,"is_corresponding":false},{"id":254357,"name":"Nordin M.J. Hanssen","orcid":"0000-0001-9541-7244","position":0,"is_corresponding":true}],"reference_count":5,"raw_metadata":null,"created_at":"2026-07-18T23:52:46.604690Z","pmid":"33434052","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}