{"doi":"10.1161/circresaha.120.317803","title":"Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease","abstract":"HomeCirculation ResearchVol. 127, No. 7Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBPlatelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease Tessa J. Barrett, Angela H. Lee, Yuhe Xia, Lawrence H. Lin, Margaret Black, Paolo Cotzia, Judith Hochman and Jeffrey S. Berger Tessa J. BarrettTessa J. Barrett Department of Medicine (T.J.B., A.H.L., Y.X., J.H., J.S.B.), New York University Grossman School of Medicine, NY. , Angela H. LeeAngela H. Lee Department of Medicine (T.J.B., A.H.L., Y.X., J.H., J.S.B.), New York University Grossman School of Medicine, NY. , Yuhe XiaYuhe Xia Department of Medicine (T.J.B., A.H.L., Y.X., J.H., J.S.B.), New York University Grossman School of Medicine, NY. , Lawrence H. LinLawrence H. Lin https://orcid.org/0000-0001-9603-9783 Department of Pathology (L.H.L., M.B., P.C.), New York University Grossman School of Medicine, NY. , Margaret BlackMargaret Black Department of Pathology (L.H.L., M.B., P.C.), New York University Grossman School of Medicine, NY. , Paolo CotziaPaolo Cotzia Department of Pathology (L.H.L., M.B., P.C.), New York University Grossman School of Medicine, NY. Center for Biospecimen Research Development (P.C.), New York University Grossman School of Medicine, NY. , Judith HochmanJudith Hochman https://orcid.org/0000-0002-5889-5981 Department of Medicine (T.J.B., A.H.L., Y.X., J.H., J.S.B.), New York University Grossman School of Medicine, NY. and Jeffrey S. BergerJeffrey S. Berger Correspondence to: Jeffrey S. Berger, MD, MS, Center for the Prevention of Cardiovascular Disease, New York University School of Medicine, 530 First Ave, Skirball 9R, New York, NY 10016. Email E-mail Address: [email protected] https://orcid.org/0000-0001-8216-4647 Department of Medicine (T.J.B., A.H.L., Y.X., J.H., J.S.B.), New York University Grossman School of Medicine, NY. Department of Surgery (J.S.B.), New York University Grossman School of Medicine, NY. Originally published6 Aug 2020https://doi.org/10.1161/CIRCRESAHA.120.317803Circulation Research. 2020;127:945–947Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: August 6, 2020: Ahead of Print The SARS-CoV-2 (SARS-CoV-2 severe acute respiratory syndrome coronavirus 2) coronavirus disease (COVID-19) is a global pandemic. Laboratory testing suggests a coagulopathy with up to 30% of hospitalized patients with COVID-19 developing thrombotic events.1 Platelets are central protagonists in both arterial and venous thrombosis, and virus-platelet interactions contribute to thrombotic risk, promoting an overall procoagulant and inflammatory states during viral infection.2 Furthermore, recent studies report platelets to be hyperactivated in subjects with COVID-19.3We speculated that in COVID-19, biomarkers of platelet activation are associated with incident thrombosis or death. Thus, we investigated in vivo surrogate biomarkers of platelet activation and vascular inflammation collected in the early phase of COVID-19 hospitalization. Plasma levels of soluble CD40 ligand (sCD40L), P-selectin, the metabolite of thromboxane A2, thromboxane B2 (TxB2), and mean platelet volume (MPV) were assessd. Venous blood samples were collected within 24 hours of hospital admission to NYU Langone Health between March 15 and April 20, 2020, in accordance with the policies of the NYU Langone Health Institutional Review Board. Plasma was collected by centrifugation of PST tubes; MPV was measured during routine care from EDTA tubes on a SYSMEX analyzer.Among 100 randomly selected hospitalized patients with COVID-19, median age was 65 years, 39 were female, 48 were White, 53 had hypertension, and at admission, 27 were on antiplatelet therapy, of whom","journal":"Circulation Research","year":2020,"id":53582,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":115,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9502,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":273873,"name":"Angela H. Lee","orcid":"0000-0001-9401-1146","position":1,"is_corresponding":false},{"id":226176,"name":"Yuhe Xia","orcid":"0000-0001-5723-7648","position":2,"is_corresponding":false},{"id":246055,"name":"Lawrence Hsu Lin","orcid":"0000-0001-9603-9783","position":3,"is_corresponding":false},{"id":246047,"name":"Margaret A. Black","orcid":"0000-0002-4239-0065","position":4,"is_corresponding":false},{"id":236057,"name":"Paolo Cotzia","orcid":"0000-0002-0710-7631","position":5,"is_corresponding":false},{"id":225667,"name":"Judith S. Hochman","orcid":"0000-0002-5889-5981","position":6,"is_corresponding":false},{"id":225663,"name":"Jeffrey S. Berger","orcid":"0000-0001-8216-4647","position":7,"is_corresponding":false},{"id":236650,"name":"Tessa J. Barrett","orcid":"0000-0003-0751-1578","position":0,"is_corresponding":true}],"reference_count":5,"raw_metadata":null,"created_at":"2026-07-18T20:45:25.145885Z","pmid":"32757722","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}