{"doi":"10.1161/circheartfailure.125.013382","title":"Heart Failure Risk and Events in People With HIV: The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE)","abstract":"BACKGROUND: People with HIV (PWH) may have a higher risk of heart failure (HF) due to traditional and HIV-related factors. Incidence and risk prediction of HF in PWH are not well characterized. We aimed to quantify the risk of HF events in a global population of PWH with low-to-moderate estimated atherosclerotic cardiovascular disease risk. METHODS: HF incidence (events/1000 person years) was described overall and by demographic, HIV-specific, and HF factors, including estimated Predicting Risk of Cardiovascular Disease Events 10-year risk of HF. Confirmed HF events included adjudicated HF hospitalization and adverse events identified via a standardized Medical Dictionary for Regulatory Archives HF query. RESULTS: We analyzed 7769 REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) participants from 5 global regions (median, 50 years; 31% female). Over a median follow-up of 5.6 years (interquartile range, 4.3-5.9), HF incidence was higher in women, among Black participants in high-income regions, participants in sub-Saharan Africa, and among those with preexisting hypertension and obesity compared with the absence of these factors. Current and nadir CD4+T-cell count, and HIV-1 RNA level were not related to the incidence of HF events. Median (Q1-Q3) Predicting Risk of Cardiovascular Disease Events HF score was 1.66% (1.01-2.62). HF incidence was 1.65/1000 person-years (95% CI, 1.30-2.09). Expected number of HF events by Predicting Risk of Cardiovascular Disease Events HF (n=73) was consistent with observed (n=67). CONCLUSIONS: Select demographics, clinical factors, and global regions contribute to a higher incidence of HF events among PWH. In PWH, the observed overall number of HF events aligned with the estimated Predicting Risk of Cardiovascular Disease Events HF risk rates.","journal":"Circulation Heart Failure","year":2025,"id":529652,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7402,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1045212,"name":"Maya Watanabe","orcid":"0009-0007-3309-2852","position":1,"is_corresponding":false},{"id":759908,"name":"Sara McCallum","orcid":"0000-0002-0289-1295","position":2,"is_corresponding":false},{"id":12096,"name":"Judith A. Aberg","orcid":"0000-0001-8162-0284","position":3,"is_corresponding":false},{"id":1280021,"name":"Aya Awwad","orcid":"0000-0003-4452-3498","position":4,"is_corresponding":false},{"id":511233,"name":"Thomas Campbell","orcid":"0000-0002-2325-4674","position":5,"is_corresponding":false},{"id":535405,"name":"Michelle Cespedes","orcid":"0000-0001-6413-150X","position":6,"is_corresponding":false},{"id":446489,"name":"Sarah M Chu","orcid":null,"position":7,"is_corresponding":false},{"id":396976,"name":"Judith S. Currier","orcid":"0000-0003-4279-4737","position":8,"is_corresponding":false},{"id":1015265,"name":"Marissa R Diggs","orcid":null,"position":9,"is_corresponding":false},{"id":442603,"name":"Craig A. Sponseller","orcid":null,"position":10,"is_corresponding":false},{"id":335272,"name":"Carl J. Fichtenbaum","orcid":"0000-0002-6778-7253","position":11,"is_corresponding":false},{"id":282485,"name":"Michael T. Lu","orcid":"0000-0003-4696-9610","position":12,"is_corresponding":false},{"id":380908,"name":"Carlos Malvestutto","orcid":"0000-0003-3156-2965","position":13,"is_corresponding":false},{"id":1087720,"name":"Gerald Pierone","orcid":"0000-0003-0159-7243","position":14,"is_corresponding":false},{"id":442618,"name":"Frank S. Rhame","orcid":null,"position":15,"is_corresponding":false},{"id":950032,"name":"Jessica Tuan","orcid":"0000-0001-7775-2444","position":16,"is_corresponding":false},{"id":471053,"name":"Sophia Zhao","orcid":"0009-0008-6914-3583","position":17,"is_corresponding":false},{"id":381595,"name":"Markella V. Zanni","orcid":"0000-0002-4711-3956","position":18,"is_corresponding":false},{"id":12007,"name":"Steven Grinspoon","orcid":"0000-0002-6338-000X","position":19,"is_corresponding":false},{"id":396977,"name":"Heather J. Ribaudo","orcid":"0000-0002-0394-3990","position":20,"is_corresponding":false},{"id":282488,"name":"Pamela S. Douglas","orcid":"0000-0001-9876-4049","position":21,"is_corresponding":false},{"id":329844,"name":"Gerald S. Bloomfield","orcid":"0000-0002-7176-1611","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T02:50:56.971987Z","pmid":"41457980","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}