{"doi":"10.1161/circheartfailure.123.010675","title":"HeartMate 3 Left Ventricular Assist Device Improves Long-Term Cerebral Hemodynamics","abstract":"he left ventricular assist device (LVAD) has revolutionized clinical management of advanced heart failure. Cerebral hemodynamic impairment is a key contributor to stroke and cognitive decline, both of which are critical considerations in an ever growing and aging LVAD population. 2 Here, we aimed to serially monitor cerebral blood flow velocity (CBFv) with transcranial Doppler before and after LVAD implantation, leveraging these data to quantify 2 dynamic measures of cerebrovascular health: cerebral autoregulation (CA) and cerebrovascular reactivity (CVR). CA describes the relationship between blood pressure (BP) and cerebral blood flow, while CVR quantifies hemodynamic reserve. Both CA and CVR are impaired in advanced heart failure, but it is unclear to what degree LVAD implantation improves these metrics. Characterizing these parameters may be crucial to understanding neurological outcomes in patients with LVAD, with the eventual goal of titrating LVAD parameters to optimize cerebral physiology.","journal":"Circulation Heart Failure","year":2023,"id":367576,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1125148,"name":"Sarah Carter","orcid":"0000-0002-1833-3239","position":1,"is_corresponding":false},{"id":344291,"name":"Pavan Atluri","orcid":"0000-0003-0229-085X","position":2,"is_corresponding":false},{"id":726152,"name":"Navpreet Reehal","orcid":"0000-0003-2813-8282","position":3,"is_corresponding":false},{"id":723312,"name":"Michael V. Genuardi","orcid":"0000-0002-8008-7526","position":4,"is_corresponding":false},{"id":726155,"name":"Christopher G. Favilla","orcid":"0000-0003-0871-9549","position":0,"is_corresponding":true}],"reference_count":7,"raw_metadata":null,"created_at":"2026-07-19T01:15:16.306414Z","pmid":"37929601","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}