{"doi":"10.1161/circheartfailure.122.009518","title":"Sarcopenic Obesity Is Associated With Reduced Cardiorespiratory Fitness Compared With Nonsarcopenic Obesity in Patients With Heart Failure With Reduced Ejection Fraction","abstract":"<jats:sec>\n            <jats:title>Background:</jats:title>\n            <jats:p>Sarcopenia impairs cardiorespiratory fitness (CRF) in patients with heart failure with reduced ejection fraction (HFrEF). Obesity has also been shown to impair CRF; however, the effects of sarcopenia on CRF in patients with obesity and HFrEF are unknown. The aim of this analysis was to examine differences in CRF between patients with sarcopenic obesity (SO) and non-SO (NSO) with HFrEF. We also assessed associations between skeletal muscle mass index (SMMI) and CRF.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Methods:</jats:title>\n            <jats:p>\n              Forty patients with HFrEF and obesity underwent cardiopulmonary exercise testing to collect measures of CRF including peak oxygen consumption (VO\n              <jats:sub>2</jats:sub>\n              ), circulatory power, oxygen uptake efficiency slope, O\n              <jats:sub>2</jats:sub>\n              pulse, and exercise time. Body composition was performed in all patients using bioelectrical impedance analysis to quantify fat mass index and divide patients into SO and NSO based on SMMI cutoffs. Results are presented as mean (SD) or median [interquartile range] as appropriate.\n            </jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Results:</jats:title>\n            <jats:p>\n              Nearly half (43% [n=17]) of patients had SO. Patients with SO had a lower SMMI than those with NSO, and no differences in fat mass index were observed between groups. Those with SO achieved a lower absolute peak VO\n              <jats:sub>2</jats:sub>\n              (NSO, 1.62±0.53 L·min\n              <jats:sup>-1</jats:sup>\n              versus SO, 1.27±0.44 L·min\n              <jats:sup>-1</jats:sup>\n              ,\n              <jats:italic>P</jats:italic>\n              =0.035), oxygen uptake efficiency slope (NSO, 1.92±0.59 versus SO, 1.54±0.48,\n              <jats:italic>P</jats:italic>\n              =0.036), and exercise time (NSO, 549±198 seconds versus SO, 413±140 seconds,\n              <jats:italic>P</jats:italic>\n              =0.021) compared to those with NSO. On multivariate analysis, SMMI remained a significant predictor of absolute peak VO\n              <jats:sub>2</jats:sub>\n              when adjusted for age, sex, adiposity, and HF severity.\n            </jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:</jats:title>\n            <jats:p>In patients with HFrEF and obesity, sarcopenia, defined as low SMMI, is associated with a clinically significant reduction in CRF, independent of adiposity.</jats:p>\n          </jats:sec>","journal":"Circulation: Heart Failure","year":2022,"id":629001,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":635099,"name":"Marco Giuseppe Del Buono","orcid":"0000-0002-7483-6164","position":1,"is_corresponding":false},{"id":373309,"name":"Justin M. Canada","orcid":"0000-0002-1342-7463","position":2,"is_corresponding":false},{"id":656780,"name":"Youngdeok Kim","orcid":"0000-0002-6134-0100","position":3,"is_corresponding":false},{"id":822433,"name":"Juan Ignacio Damonte","orcid":"0000-0002-8064-1363","position":4,"is_corresponding":false},{"id":432504,"name":"Cory R. Trankle","orcid":"0000-0002-3891-7004","position":5,"is_corresponding":false},{"id":1628846,"name":"Geza Halasz","orcid":"0000-0001-7220-123X","position":6,"is_corresponding":false},{"id":668514,"name":"Virginia Mihalick","orcid":null,"position":7,"is_corresponding":false},{"id":760576,"name":"Alessandra Vecchié","orcid":"0000-0003-0410-5996","position":8,"is_corresponding":false},{"id":1628847,"name":"Roshanak R. Markley","orcid":"0000-0001-9676-3333","position":9,"is_corresponding":false},{"id":635101,"name":"Dinesh Kadariya","orcid":"0000-0001-5932-477X","position":10,"is_corresponding":false},{"id":1628848,"name":"Edoardo Bressi","orcid":"0000-0002-8080-6842","position":11,"is_corresponding":false},{"id":1628849,"name":"Horacio Medina de Chazal","orcid":null,"position":12,"is_corresponding":false},{"id":635100,"name":"Juan Guido Chiabrando","orcid":"0000-0002-2128-8280","position":13,"is_corresponding":false},{"id":1149508,"name":"James Mbualungu","orcid":null,"position":14,"is_corresponding":false},{"id":635840,"name":"Jeremy Turlington","orcid":null,"position":15,"is_corresponding":false},{"id":707848,"name":"Ross Arena","orcid":"0000-0002-6675-1996","position":16,"is_corresponding":false},{"id":635103,"name":"Benjamín Van Tassell","orcid":"0000-0003-0688-4487","position":17,"is_corresponding":false},{"id":304978,"name":"Antonio Abbate","orcid":"0000-0002-1930-785X","position":18,"is_corresponding":false},{"id":277053,"name":"Salvatore Carbone","orcid":"0000-0002-8163-0527","position":19,"is_corresponding":false},{"id":277052,"name":"Hayley Billingsley","orcid":"0000-0002-6239-467X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Sarcopenic Obesity Is Associated With Reduced Cardiorespiratory Fitness Compared With Nonsarcopenic Obesity in Patients With Heart Failure With Reduced Ejection Fraction","abstract":"<jats:sec>\n            <jats:title>Background:</jats:title>\n            <jats:p>Sarcopenia impairs cardiorespiratory fitness (CRF) in patients with heart failure with reduced ejection fraction (HFrEF). Obesity has also been shown to impair CRF; however, the effects of sarcopenia on CRF in patients with obesity and HFrEF are unknown. The aim of this analysis was to examine differences in CRF between patients with sarcopenic obesity (SO) and non-SO (NSO) with HFrEF. We also assessed associations between skeletal muscle mass index (SMMI) and CRF.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Methods:</jats:title>\n            <jats:p>\n              Forty patients with HFrEF and obesity underwent cardiopulmonary exercise testing to collect measures of CRF including peak oxygen consumption (VO\n              <jats:sub>2</jats:sub>\n              ), circulatory power, oxygen uptake efficiency slope, O\n              <jats:sub>2</jats:sub>\n              pulse, and exercise time. Body composition was performed in all patients using bioelectrical impedance analysis to quantify fat mass index and divide patients into SO and NSO based on SMMI cutoffs. Results are presented as mean (SD) or median [interquartile range] as appropriate.\n            </jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Results:</jats:title>\n            <jats:p>\n              Nearly half (43% [n=17]) of patients had SO. Patients with SO had a lower SMMI than those with NSO, and no differences in fat mass index were observed between groups. Those with SO achieved a lower absolute peak VO\n              <jats:sub>2</jats:sub>\n              (NSO, 1.62±0.53 L·min\n              <jats:sup>-1</jats:sup>\n              versus SO, 1.27±0.44 L·min\n              <jats:sup>-1</jats:sup>\n              ,\n              <jats:italic>P</jats:italic>\n              =0.035), oxygen uptake efficiency slope (NSO, 1.92±0.59 versus SO, 1.54±0.48,\n              <jats:italic>P</jats:italic>\n              =0.036), and exercise time (NSO, 549±198 seconds versus SO, 413±140 seconds,\n              <jats:italic>P</jats:italic>\n              =0.021) compared to those with NSO. On multivariate analysis, SMMI remained a significant predictor of absolute peak VO\n              <jats:sub>2</jats:sub>\n              when adjusted for age, sex, adiposity, and HF severity.\n            </jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:</jats:title>\n            <jats:p>In patients with HFrEF and obesity, sarcopenia, defined as low SMMI, is associated with a clinically significant reduction in CRF, independent of adiposity.</jats:p>\n          </jats:sec>","is_dataset_classified":null,"base_score":3.912023005428146,"endowment":3.912023005428146,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36098058","pmcid":"PMC9588574","openalex_id":"https://openalex.org/W4295512286","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"R33 HL139943","title":null},{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR002649","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R61 HL139943","title":null},{"funder_name":"National Institutes of Health","grant_id":"5UL1TR002649-02","title":"Center for Clinical and Translational Research"},{"funder_name":"National Institutes of Health","grant_id":"1R61HL139943-01","title":"The Effects of Interleukin-1 Blockade On Exercise Capacity In Patients With Recently Decompensated Systolic Heart Failure"}],"total_grants":5,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":11},{"year":2024,"count":10},{"year":2025,"count":16},{"year":2026,"count":11}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCHEARTFAILURE.122.009518","host_type":"journal"},{"url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCHEARTFAILURE.122.009518","host_type":"publisher"},{"url":"https://www.ahajournals.org/doi/full/10.1161/CIRCHEARTFAILURE.122.009518","host_type":"publisher"},{"url":"https://doi.org/10.1161/circheartfailure.122.009518","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36098058","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9588574","host_type":"repository"}],"fields_of_study":["Nutrition and Health in Aging","Cardiovascular Function and Risk Factors","Cardiovascular and exercise physiology","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Cardiorespiratory Fitness","Exercise Test","Heart Failure","Humans","Obesity","Oxygen","Oxygen Consumption","Stroke Volume","Sarcopenia"],"keywords":["Cardiorespiratory fitness","Medicine","Internal medicine","Cardiology","Ejection fraction","Heart failure","Bioelectrical impedance analysis","Interquartile range","Sarcopenia","VO2 max","Obesity","Body mass index","Oxygen pulse","Sarcopenic obesity","Heart rate","Blood pressure","risk","Oxygen","Oxygen Consumption","Exercise Test","Humans","Stroke Volume"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. 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