{"doi":"10.1161/atvbaha.123.319563","title":"Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community","abstract":"Valvular heart disease (VHD) takes a central stage in contemporary cardiology due to population aging and immense progress in percutaneous approaches to its treatment. VHD continues to be a major cause of death and suffering in both developed countries and low-and middle-income countries. In the United States, moderate-to-severe VHD occurs in 13.2% of people aged 75 years, with 2.8% for symptomatic calcific aortic stenosis and 9.3% for mitral valve regurgitation. Strikingly, there are no effective or approved medicines for any form of VHD. The only available therapy remains valve repair or replacement, which is a highly specialized, invasive, and costly procedure primarily performed in late-stage disease and often unavailable in developing countries.","journal":"Arteriosclerosis Thrombosis and Vascular Biology","year":2024,"id":484410,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":559212,"name":"Mark C. Blaser","orcid":"0000-0002-3923-9786","position":1,"is_corresponding":false},{"id":364514,"name":"Sasha A. Singh","orcid":"0000-0003-0929-3164","position":2,"is_corresponding":false},{"id":286119,"name":"Robert A. Levine","orcid":"0000-0002-9484-8218","position":3,"is_corresponding":false},{"id":472794,"name":"Magdi H. Yacoub","orcid":"0000-0001-9070-8245","position":4,"is_corresponding":false},{"id":305056,"name":"Elena Aïkawa","orcid":"0000-0001-7835-2135","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T02:07:42.971417Z","pmid":"38536897","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}