{"doi":"10.1161/01.cir.72.6.1202","title":"Thromboxane A2 and prostaglandin endoperoxide receptors in platelets and vascular smooth muscle.","abstract":"<jats:p>9,11-Dimethylmethano-11,12-methano-16-(3-iodo-4-hydroxyphenyl)-13, 14-dihydro-13-aza-15 alpha beta-omega-tetranor-TXA2 (I-PTA-OH), a recently synthesized thromboxane (TX) A2/prostaglandin (PG) H2 receptor antagonist, was shown to be a competitive antagonist of human platelet aggregation induced by the stable endoperoxide analog U46619. This antagonism was due to competitive blockade of the platelet TXA2/PGH2 receptor since I-PTA-OH did not antagonize the first phase of ADP-induced aggregation which is TXA2/PGH2 independent, nor did it inhibit TXA2 synthesis. In addition, analysis of dose-response curves to U46619 (0.1 to 40 microM) in the presence of increasing concentrations of I-PTA-OH (0.5 to 10 microM) showed that I-PTA-OH produced a parallel rightward shift of the dose-response curve. Further analysis of the data in the form of a Schild plot yielded a straight line with a slope (m = 1.03) not significantly different from -1. These results are consistent with the notion that I-PTA-OH acts as a competitive antagonist of the TXA2/PGH2 receptor.</jats:p>","journal":"Circulation","year":1985,"id":29635,"datarank":2.0424030055337274,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":1.504875164765311,"self_endowment_contribution":0.5375278407684165,"citer_contribution":1.504875164765311,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":26,"citers_with_citation_signal":23,"citers_with_endowment":23,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":162972,"name":"D E Mais","orcid":null,"position":1,"is_corresponding":false},{"id":162973,"name":"D R Knapp","orcid":null,"position":2,"is_corresponding":false},{"id":162974,"name":"P V Halushka","orcid":null,"position":3,"is_corresponding":false},{"id":162971,"name":"D L Saussy","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.58351893845611,"endowment":3.58351893845611,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"2998641","pmcid":null,"openalex_id":"https://openalex.org/W1984350873","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"HL 07260","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL 29566","title":null}],"total_grants":2,"fwci":4.0669,"citation_percentile":0.94217986,"influential_citations":1,"citation_trend":[{"year":2012,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.72.6.1202","host_type":"journal"},{"url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.72.6.1202","host_type":"BRONZE"},{"url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.72.6.1202","host_type":"publisher"},{"url":"https://doi.org/10.1161/01.cir.72.6.1202","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/2998641","host_type":"repository"}],"fields_of_study":["Inflammatory mediators and NSAID effects","Eicosanoids and Hypertension Pharmacology","Nitric Oxide and Endothelin Effects","Medicine","Biology","15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid","Blood Platelets","Humans","Iodine Radioisotopes","Male","Muscle, Smooth, Vascular","Platelet Aggregation","Prostaglandin Endoperoxides","Prostaglandin Endoperoxides, Synthetic","Radioligand Assay","Receptors, Cell Surface","Receptors, Prostaglandin","Receptors, Thromboxane","Structure-Activity Relationship","Thromboxane A2"],"mesh_terms":["Blood Platelets","Humans","Iodine Radioisotopes","Male","Muscle, Smooth, Vascular","Platelet Aggregation","Prostaglandin Endoperoxides","Prostaglandin Endoperoxides, Synthetic","Radioligand Assay","Receptors, Cell Surface","Receptors, Prostaglandin","Structure-Activity Relationship","Thromboxane A2","Receptors, Thromboxane","15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"],"keywords":["Thromboxane A2","Prostaglandin H2","Schild regression","Antagonist","Antagonism","Receptor antagonist","Thromboxane","Platelet","Competitive antagonist","Receptor","Prostaglandin","Medicine","Thromboxane receptor","Internal medicine","Endocrinology","Pharmacology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T00:21:17.295155Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}