{"doi":"10.1160/th05-07-0488","title":"Endothelial tight junctions: permeable barriers of the vessel wall","abstract":"<jats:title>Summary</jats:title><jats:p>The endothelial lining of the vessel wall is a permeable barrier, which is located at the interface between the vascular and the perivascular compartments. Although the endothelium acts as an efficient barrier that strictly separates the two compartments,it may also act as a permeable filter which allows selective exchange of solutes and water between the luminal and abluminal sides of the barrier. Similarly to epithelia, also in the endothelium permeability follows two distinct routes, which have been termed transcellular pathway (across the apical and basolateral membranes of individual cells) and paracellular pathway (through the intercellular junctions and the lateral spaces between contacting cells). After an initial description of the two pathways, the review focuses on the cellular and molecular basis of the paracellular pathway, with emphasis on the role of intercellular tight junctions and tight junction-associated claudins. Finally, the signaling events that regulate paracellular permeability are discussed.</jats:p>","journal":"Thrombosis and Haemostasis","year":2006,"id":42923,"datarank":6.0398519672573885,"base_score":4.897839799950911,"endowment":4.897839799950911,"self_citation_contribution":0.7346759699926367,"citation_network_contribution":5.305175997264752,"self_endowment_contribution":0.7346759699926367,"citer_contribution":5.305175997264752,"corpus_percentile":null,"corpus_rank":null,"citation_count":133,"citer_count":131,"citers_with_citation_signal":116,"citers_with_endowment":116,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":204691,"name":"Gianfranco Bazzoni","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.897839799950911,"endowment":4.897839799950911,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16543959","pmcid":null,"openalex_id":"https://openalex.org/W2077340378","authors":[],"funders":[{"funder_name":"AICR (Association International for Cancer Research)","grant_id":"04-095","title":null},{"funder_name":"MIUR (Ministry of Education, University and Research)","grant_id":"RBNE01T8C8_004 and RBAU01E5F5","title":null}],"total_grants":2,"fwci":6.2038,"citation_percentile":0.96156335,"influential_citations":5,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":10},{"year":2014,"count":12},{"year":2015,"count":7},{"year":2016,"count":7},{"year":2017,"count":9},{"year":2018,"count":7},{"year":2019,"count":6},{"year":2020,"count":5},{"year":2021,"count":3},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":6},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH05-07-0488.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1160/th05-07-0488","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16543959","host_type":"repository"}],"fields_of_study":["Barrier Structure and Function Studies","Neurological Disease Mechanisms and Treatments","Connexins and lens biology","Biology","Medicine"],"mesh_terms":["Animals","Capillary Permeability","Cell Adhesion","Cell Communication","Endothelium, Vascular","Humans","Membrane Proteins","Models, Biological","Protein Conformation","Protein Kinase C","Protein-Tyrosine Kinases","Signal Transduction","Cell Adhesion Molecules","Tight Junctions","Claudin-1","Junctional Adhesion Molecules","Occludin"],"keywords":["Paracellular transport","Tight junction","Transcellular","Cell junction","Claudin","Cell biology","Endothelium","Intracellular","Endothelial stem cell","Adherens junction","Permeability (electromagnetism)","Vascular permeability","Caveolae","Biophysics","Chemistry","Biology","Signal transduction","Membrane","Cell","Cadherin","Biochemistry","In vitro"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-14T08:45:57.229414Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}