{"doi":"10.1159/000546296","title":"Intradialytic Cognitive and Aerobic Exercise Training to Preserve Cognitive Function: IMPCT, a Multi-Dialysis Center 2 × 2 Factorial Block-Randomized Controlled Trial","abstract":"Introduction: Patients with end-stage kidney disease develop cognitive impairment due to comorbidities and dialysis dependence. Among community-dwelling older adults, cognitive (CT) and exercise training (ET) are promising interventions to preserve cognition; these interventions may be tailored for adults undergoing in-center hemodialysis. METHODS: Adult (≥18 years) English-speaking patients undergoing hemodialysis (within 3 months to 3 years of initiation) were enrolled in a 2 × 2 factorial randomized controlled trial: Interventions Made to Preserve Cognitive Function Trial (IMPCT). Participants (n = 121) were block-randomized (September, 2018-February, 2023) into 4 arms: control (SC) (n = 26), intradialytic web-based CT (n = 31), ET using foot peddler (n = 29), and combined CT+ET (n = 35). Participants underwent assessments at baseline and 3 months for executive function, global cognitive function, clinical outcomes, and patient-centered outcomes. We estimated 3-month executive function change (primary outcome) and secondary outcomes using linear regression. RESULTS: There were no differences in 3-month executive function change by arm. Participants exhibited improvement in 3-month global cognitive function in CT+ET arm (Montreal Cognitive Assessment score difference = 2.1, 95% CI: 0.4-3.9), and self-reported 3-month improvement in perceived health change (score difference = 0.8, 95% CI: 0.2-1.4) in ET arm. CONCLUSION: Clinicians may encourage CT+ET for hemodialysis patients to improve short-term global cognitive function and perceived health. The long-term benefits of these interventions warrant further study. .","journal":"American Journal of Nephrology","year":2025,"id":517390,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":388696,"name":"Yi Liu","orcid":"0000-0003-0169-1125","position":1,"is_corresponding":false},{"id":674990,"name":"Jingyao Hong","orcid":"0000-0002-8156-1306","position":2,"is_corresponding":false},{"id":1383660,"name":"Yiting Li","orcid":"0000-0002-0384-0879","position":3,"is_corresponding":false},{"id":652895,"name":"Xiaomeng Chen","orcid":"0000-0001-9620-7361","position":4,"is_corresponding":false},{"id":401504,"name":"Marlís González‐Fernández","orcid":"0000-0002-1576-3452","position":5,"is_corresponding":false},{"id":286279,"name":"Michelle C. Carlson","orcid":"0000-0003-2465-7421","position":6,"is_corresponding":false},{"id":285332,"name":"Derek M. Fine","orcid":"0000-0003-2838-2058","position":7,"is_corresponding":false},{"id":277163,"name":"Lawrence J. Appel","orcid":"0000-0002-0673-6823","position":8,"is_corresponding":false},{"id":420041,"name":"Marie Diener‐West","orcid":"0000-0002-3082-1323","position":9,"is_corresponding":false},{"id":225665,"name":"David M. Charytan","orcid":"0000-0002-7695-3583","position":10,"is_corresponding":false},{"id":378272,"name":"Aarti Mathur","orcid":"0000-0002-9693-7433","position":11,"is_corresponding":false},{"id":257567,"name":"Dorry L. Segev","orcid":"0000-0002-1924-4801","position":12,"is_corresponding":false},{"id":257566,"name":"Mara McAdams‐DeMarco","orcid":"0000-0003-3013-925X","position":13,"is_corresponding":false},{"id":758726,"name":"Nidhi Ghildayal","orcid":"0000-0002-7792-3431","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:48:59.410472Z","pmid":"40349685","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}