{"doi":"10.1159/000537949","title":"Sensitivity of Magnetic Resonance Imaging in Detection of Choroidal Metastases","abstract":"<b><i>Introduction:</i></b> The objective of this study was to determine the sensitivity of brain magnetic resonance imaging (MRI) in the detection of choroidal metastasis (CM) from systemic primary cancers. <b><i>Methods:</i></b> A retrospective chart review identified patients with clinically confirmed CM seen on the Oncology Service (Byers Eye Institute) between January 2018 and March 2022. Patients had an MRI brain and/or orbits performed within 3 months of CM diagnosis. Evaluation of CM detection by MRI was then divided into two parts: an initial “standard read,” where determination of CM detection was based solely on the original radiology report, to reflect real-world performance, and a subsequent “dedicated read,” for which a board-certified neuroradiologist, blinded to the laterality and location of the CM, reevaluated the studies to provide an objective “gold standard” interpretation regarding the radiographic detection of CM. <b><i>Results:</i></b> The study included 42 eyes of 40 patients with confirmed CM. On standard read, MRI detection of CM occurred in 21 of 42 eyes (50%), with no significant difference between MRI brain and orbit protocols (<i>p =</i> 0.249). Features associated with improved detection were increased tumor basal diameter (<i>p</i> < 0.001) and ultrasonographic tumor thickness (<i>p</i> = 0.003). On dedicated read, MRI detection of CM improved to 26 of 33 eyes (76%; limited to eyes with full complement of pre- and post-gadolinium sequences). Post-gadolinium 3D fluid-attenuated inversion recovery (FLAIR) sequence with fat suppression was the most sensitive (88%) for CM detection. 42% and 58% of lesions were visualized using conventional pre-gadolinium T1- and T2-weighted imaging, respectively. <b><i>Conclusions:</i></b> MRI sensitivity to detect CM improved from 50% to 76% with focused reinterpretation. Increased utilization of the post-gadolinium 3D FLAIR sequence and increased ocular scrutiny in cancer patients undergoing brain imaging may facilitate earlier diagnosis of CM.","journal":"Ocular Oncology and Pathology","year":2024,"id":461899,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":316801,"name":"Sarah Miller","orcid":"0000-0003-4251-8126","position":1,"is_corresponding":false},{"id":920784,"name":"Hashem Ghoraba","orcid":"0000-0002-1145-4134","position":2,"is_corresponding":false},{"id":1291368,"name":"Luis E Sabage","orcid":null,"position":3,"is_corresponding":false},{"id":1291369,"name":"Nancy J Fischbein","orcid":null,"position":4,"is_corresponding":false},{"id":481036,"name":"Prithvi Mruthyunjaya","orcid":"0000-0003-1087-9736","position":5,"is_corresponding":false},{"id":1290859,"name":"Michael D. Yu","orcid":"0000-0002-4771-2211","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T02:04:16.410510Z","pmid":"38882019","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}