{"doi":"10.1159/000534258","title":"Association between F2-Isoprostane Metabolites and Weight Change in Older Women: A Longitudinal Analysis","abstract":"INTRODUCTION: Theoretically, some metabolic traits may predispose older individuals to weight loss during aging, leading to increased all-cause mortality and many serious health issues. Biomarkers to robustly predict progressive weight loss during aging are, however, lacking. We prospectively assessed if urinary levels of F2-isoprostanes and their peroxisomal β-oxidation metabolite, 2,3-dinor-5,6-dihydro-15-F2t-isoprostane (F2-IsoP-M), were associated with subsequent weight loss in middle-aged and older women. METHODS: Included in the analysis were 2,066 women aged 40-70 years, a subset of a prospective cohort study. F2-isoprostanes (F2-IsoPs) and its β-oxidation metabolite, F2-IsoP-M, were measured in urine using gas chromatography-mass spectrometry. Measurements of anthropometry and exposures to major determinants of body weight were performed at baseline and repeated thrice over 15-year follow-up. The longitudinal associations of F2-IsoP-M and the F2-IsoP-M to its parent compound, F2-IsoP, ratio (MPR) with repeatedly measured weight changes were examined using linear mixed-effect models. RESULTS: After adjusting for time-varying covariates: energy intake, physical activity, and comorbidity index, among others, levels of F2-IsoP-M and the MPR were both inversely associated with percentage of weight change. Weight in the highest quartile of these two biomarkers was 1.33% (95% CI = -2.41, -0.24) and 1.09% (95% CI = -2.16, -0.02) lower than those in the lowest quartile group, with p for trend of 0.01 and 0.03, respectively. The inverse association was consistently seen across follow-up periods, although appearing stronger with prolonged follow-up. There was no association between the parent compound, F2-IsoPs, and weight change. CONCLUSION: This study demonstrates the first piece of evidence to associate F2-IsoP metabolism, peroxisomal β-oxidation, with weight loss in older women. Further investigations into the role of lipid peroxidation and peroxisomal β-oxidation in weight change among older individuals are warranted.","journal":"Gerontology","year":2023,"id":377980,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":943157,"name":"Marina Sayuri Nogueira","orcid":"0000-0001-8092-928X","position":1,"is_corresponding":false},{"id":404612,"name":"Qingxia Chen","orcid":"0000-0003-0507-1847","position":2,"is_corresponding":false},{"id":45052,"name":"Qi Dai","orcid":"0000-0002-2082-0693","position":3,"is_corresponding":false},{"id":86849,"name":"Qiuyin Cai","orcid":"0000-0002-9384-5648","position":4,"is_corresponding":false},{"id":259911,"name":"Wanqing Wen","orcid":"0000-0002-3004-5168","position":5,"is_corresponding":false},{"id":1141558,"name":"Qing Lan","orcid":"0000-0001-7791-5020","position":6,"is_corresponding":false},{"id":96418,"name":"Nathaniel Rothman","orcid":"0000-0001-6924-0895","position":7,"is_corresponding":false},{"id":291446,"name":"Yu‐Tang Gao","orcid":"0000-0003-3904-1777","position":8,"is_corresponding":false},{"id":240065,"name":"Xiao‐Ou Shu","orcid":"0000-0002-0711-8314","position":9,"is_corresponding":false},{"id":39347,"name":"Wei Zheng","orcid":"0000-0003-1226-070X","position":10,"is_corresponding":false},{"id":297595,"name":"Ginger L. Milne","orcid":"0000-0003-3890-151X","position":11,"is_corresponding":false},{"id":369712,"name":"Gong Yang","orcid":"0000-0002-7006-5825","position":12,"is_corresponding":false},{"id":748990,"name":"Yingya Zhao","orcid":null,"position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:16:40.346877Z","pmid":"37967546","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}