{"doi":"10.1159/000518234","title":"Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period","abstract":"<b><i>Introduction:</i></b> We evaluated the association between carotid compliance, a measure of arterial stiffness, to parahippocampal volume (PHV) and hippocampal volume (HV) over 20 years later in the Atherosclerosis Risk in the Community study. <b><i>Methods:</i></b> We included participants with common carotid compliance measurements at visit 1 (1987–1989) and volumetric brain MRI at visit 5 (2011–2013). The primary outcomes are pooled bilateral PHV and HV. We performed linear regression models adjusting for age, sex, vascular risk factors, and total brain volume. <b><i>Results:</i></b> Of the 614 participants, higher compliance was correlated with higher PHV (<i>R</i> = 0.218[0.144–0.291], <i>p</i> < 0.001) and HV (<i>R</i> = 0.181 [0.105–0.255, <i>p</i> < 0.001]). The association was linear and significant after adjusting for confounders. At follow-up MRI, 30 patients with dementia had lower PHV and HV than patients without dementia (<i>p</i> < 0.001 and <i>p</i> < 0.001, respectively). <b><i>Conclusion:</i></b> Carotid compliance is associated with higher PHV and HV when measured 20 years later, further supporting the link between arterial stiffness and cognitive decline.","journal":"Dementia and Geriatric Cognitive Disorders Extra","year":2021,"id":210015,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5387,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":554278,"name":"Alen Delic","orcid":"0000-0003-1519-0807","position":1,"is_corresponding":false},{"id":441763,"name":"J. Scott McNally","orcid":"0000-0003-3770-1153","position":2,"is_corresponding":false},{"id":409193,"name":"Matthew D. Alexander","orcid":"0000-0002-7534-5842","position":3,"is_corresponding":false},{"id":525854,"name":"Jennifer J. Majersik","orcid":"0000-0003-3191-262X","position":4,"is_corresponding":false},{"id":388330,"name":"Dennis L. Parker","orcid":"0000-0003-2557-8952","position":5,"is_corresponding":false},{"id":421725,"name":"Adam de Havenon","orcid":"0000-0001-8178-8597","position":6,"is_corresponding":false},{"id":317219,"name":"Hediyeh Baradaran","orcid":"0000-0002-6251-5769","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-18T23:52:08.869117Z","pmid":"34721500","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}